Ciências Odontológicas

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http://repositorio.ufes.br/handle/10/17573
Programa de Pós-Graduação em Ciências Odontológicas

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Navegando Ciências Odontológicas por Assunto "Biópsia"

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    Acurácia da autofluorescência para diagnóstico precoce de desordens orais potencialmente malignas: revisão sistemática
    (Universidade Federal do Espírito Santo, 2023-07-14) Freitas, Lara Weinert de; Barros, Liliana Aparecida Pimenta de; http://lattes.cnpq.br/8635277660080840; https://orcid.org/0000-0001-5999-0713; http://lattes.cnpq.br/9739624818971642; Lima, Thiago Farias Rocha; http://lattes.cnpq.br/3369191934450137; Lourenco, Simone de Queiroz Chaves
    Studies involving new tests and diagnostic methods used to screen for lesions that precede oral cancer are carried out, however, it becomes necessary to investigate the diagnostic accuracy index for its application. The objective of this Systematic Review (RS) was to collect the accuracy of autofluorescence in the early diagnosis of oral disorders with malignant potential (ODMPs). The search was carried out in nine electronic databases, three of which were gray literature, with no language or time restrictions. The studies included patients with ODMPs with microscopic examination – standard reference – obligatorily as a comparison to the autofluorescence method (test index). In selecting the two-phase studies, 17 of 3429 studies were included. The QUADAS-2 tool was used for risk of bias analysis with support from the Review Manager 5.0 tool for risk of bias analysis. The sensitivity and specificity of the studies varied considerably, with a minimum of 30% and a maximum of 100% for sensitivity, and a minimum of 15% and a maximum of 100% for specificity, which demonstrates exceptional accuracy within the studies. The risk of bias was low in most studies in domain 1 (patient selection) and unclear in most studies in domains 2 (index test), 3 (reference standard) and 4 (flow and time). The sensitivity and specificity of the studies varied considerably, with a minimum of 30 and a maximum of 100 for sensitivity and a minimum of 15 and a maximum of 100 for specificity, which demonstrates intellectual accuracy within the studies. The risk of bias was low in most studies in domain 1 (patient selection) and it was not clear in domains 2 (index test), 3 (reference standard) and 4 (flow and time). The autofluorescence of the selected studies showed moderate to uncertain accuracy due to the heterogeneity of the results and raises an alert for the development of more primary studies consistent in design and conduct.The applicability of autofluorescence in aiding the diagnosis of ODMPs should prosper ecause it is a non-invasive method, easy to handle, accessible in the dentist's routine, despite the variable cost, ubject to the standardization of protocols and the physician's experience., more studies are necessary due to the analysis of the risk of bias and the asymmetry of the sensitivity and specificity of the results.
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    Acurácia do dispositivo VELscope® para diagnóstico complementar de desordens orais potencialmente malignas (DOPMs)
    (Universidade Federal do Espírito Santo, 2023-12-19) Jesus, Eduarda Barboza Layber de; Barros, Liliana Aparecida Pimenta de; http://lattes.cnpq.br/8635277660080840; https://orcid.org/0009-0005-7083-4144; http://lattes.cnpq.br/4167117921403314; Barroso, Danielle Resende Camisasca; http://lattes.cnpq.br/3989074593181674; Lourenco, Simone de Queiroz Chaves
    The early diagnosis of oral potentially malignant disorders (OPMDs) through visual inspection followed by histopathological confirmation is a fundamental step towards reducing the rates of lesions that have undergone malignant transformation. The use of the VELscope device has been suggested as an adjuvant tool through fluorescence visualization in the early detection of OPMDs. The aim of our study was to characterize the diagnostic accuracy of the VELscope in recognizing the autofluorescence of OPMDs, correlating clinical and histopathological aspects. Fifty-six oral mucosa lesions were submitted to conventional oral examination (COE) followed by VELscope and their autofluorescence characteristics were compared with the histopathological diagnosis. Sensitivity, specificity, positive and negative predictive values, accuracy and positive and negative likelihood ratios were calculated. The VELscope test showed sensitivity and specificity values of 50% and 69%, respectively, while the positive predictive value was 47.6% and the negative predictive value 71.4%. The overall accuracy was 62.5% and the positive and negative likelihood ratios were 1.63 and 0.72, respectively. The VELscope exam alone cannot provide a definitive diagnosis regarding the presence of dysplastic tissue changes and high-risk lesions. Despite having reasonable sensitivity, the high number of false-positive and false-negative results limits its effectiveness as an adjuvant, reinforced by the unfavorable negative likelihood ratio. A comprehensive and systematic conventional oral examination, biopsy and histopathological evaluation are the reference standards for the evaluation of suspicious lesions of the oral mucosa, considering the low accuracy of the VELscope device as an auxiliary method equipment in clinical examination.