Ciências Odontológicas

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Programa de Pós-Graduação em Ciências Odontológicas

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Acurácia da autofluorescência para diagnóstico precoce de desordens orais potencialmente malignas: revisão sistemática
(Universidade Federal do Espírito Santo, 2023-07-14) Freitas, Lara Weinert de; Barros, Liliana Aparecida Pimenta de; http://lattes.cnpq.br/8635277660080840; https://orcid.org/0000-0001-5999-0713; http://lattes.cnpq.br/9739624818971642; Lima, Thiago Farias Rocha; http://lattes.cnpq.br/3369191934450137; Lourenco, Simone de Queiroz Chaves
Studies involving new tests and diagnostic methods used to screen for lesions that precede oral cancer are carried out, however, it becomes necessary to investigate the diagnostic accuracy index for its application. The objective of this Systematic Review (RS) was to collect the accuracy of autofluorescence in the early diagnosis of oral disorders with malignant potential (ODMPs). The search was carried out in nine electronic databases, three of which were gray literature, with no language or time restrictions. The studies included patients with ODMPs with microscopic examination – standard reference – obligatorily as a comparison to the autofluorescence method (test index). In selecting the two-phase studies, 17 of 3429 studies were included. The QUADAS-2 tool was used for risk of bias analysis with support from the Review Manager 5.0 tool for risk of bias analysis. The sensitivity and specificity of the studies varied considerably, with a minimum of 30% and a maximum of 100% for sensitivity, and a minimum of 15% and a maximum of 100% for specificity, which demonstrates exceptional accuracy within the studies. The risk of bias was low in most studies in domain 1 (patient selection) and unclear in most studies in domains 2 (index test), 3 (reference standard) and 4 (flow and time). The sensitivity and specificity of the studies varied considerably, with a minimum of 30 and a maximum of 100 for sensitivity and a minimum of 15 and a maximum of 100 for specificity, which demonstrates intellectual accuracy within the studies. The risk of bias was low in most studies in domain 1 (patient selection) and it was not clear in domains 2 (index test), 3 (reference standard) and 4 (flow and time). The autofluorescence of the selected studies showed moderate to uncertain accuracy due to the heterogeneity of the results and raises an alert for the development of more primary studies consistent in design and conduct.The applicability of autofluorescence in aiding the diagnosis of ODMPs should prosper ecause it is a non-invasive method, easy to handle, accessible in the dentist's routine, despite the variable cost, ubject to the standardization of protocols and the physician's experience., more studies are necessary due to the analysis of the risk of bias and the asymmetry of the sensitivity and specificity of the results.
Acurácia do dispositivo VELscope® para diagnóstico complementar de desordens orais potencialmente malignas (DOPMs)
(Universidade Federal do Espírito Santo, 2023-12-19) Jesus, Eduarda Barboza Layber de; Barros, Liliana Aparecida Pimenta de; http://lattes.cnpq.br/8635277660080840; https://orcid.org/0009-0005-7083-4144; http://lattes.cnpq.br/4167117921403314; Barroso, Danielle Resende Camisasca; http://lattes.cnpq.br/3989074593181674; Lourenco, Simone de Queiroz Chaves
The early diagnosis of oral potentially malignant disorders (OPMDs) through visual inspection followed by histopathological confirmation is a fundamental step towards reducing the rates of lesions that have undergone malignant transformation. The use of the VELscope device has been suggested as an adjuvant tool through fluorescence visualization in the early detection of OPMDs. The aim of our study was to characterize the diagnostic accuracy of the VELscope in recognizing the autofluorescence of OPMDs, correlating clinical and histopathological aspects. Fifty-six oral mucosa lesions were submitted to conventional oral examination (COE) followed by VELscope and their autofluorescence characteristics were compared with the histopathological diagnosis. Sensitivity, specificity, positive and negative predictive values, accuracy and positive and negative likelihood ratios were calculated. The VELscope test showed sensitivity and specificity values of 50% and 69%, respectively, while the positive predictive value was 47.6% and the negative predictive value 71.4%. The overall accuracy was 62.5% and the positive and negative likelihood ratios were 1.63 and 0.72, respectively. The VELscope exam alone cannot provide a definitive diagnosis regarding the presence of dysplastic tissue changes and high-risk lesions. Despite having reasonable sensitivity, the high number of false-positive and false-negative results limits its effectiveness as an adjuvant, reinforced by the unfavorable negative likelihood ratio. A comprehensive and systematic conventional oral examination, biopsy and histopathological evaluation are the reference standards for the evaluation of suspicious lesions of the oral mucosa, considering the low accuracy of the VELscope device as an auxiliary method equipment in clinical examination.
Análise Clínica e Micológica da Colonização Por Candida spp. em Leucoplasia Oral e Líquen Plano Oral
(Universidade Federal do Espírito Santo, 2024-01-23) Novo, Vinícius Matos; Gonçalves, Sarah Santos; https://orcid.org/0000-0003-4170-4445; http://lattes.cnpq.br/1018708169217296; Velloso, Tânia Regina Grão; https://orcid.org/0000-0001-6865-7955; http://lattes.cnpq.br/6427157237870625; https://orcid.org/0000-0002-5892-210X; http://lattes.cnpq.br/4757635191749255; Velloso, Tânia Regina Grão; https://orcid.org/0000-0001-6865-7955; http://lattes.cnpq.br/6427157237870625; Barros, Liliana Aparecida Pimenta de; https://orcid.org/0000-0002-1649-3116; http://lattes.cnpq.br/8635277660080840; Pigatti, Fernanda Mombrini; https://orcid.org/0000-0001-8495-8571; http://lattes.cnpq.br/8243371686189167
Colonization/infection by Candida spp. has been associated with a variety of oral entities, including oral leukoplakia and oral lichen planus, which are termed potentially malignant disorders of the oral cavity. These clinical conditions present distinct characteristics but share similarities in relation to etiological factors such as immunosuppression, chronic inflammation, and alterations in oral microbiota. Understanding the relationship between Candida spp. colonization and these lesions is fundamental for effective diagnosis and clinical management. This study aims to assess the prevalence of Candida colonization, delineate the demographic and clinical profile, phenotypically, biochemically, and molecularly identify Candida isolates, examine systemic and local factors contributing to Candida colonization and/or infection in oral leukoplakia and oral lichen planus, and investigate potential differences in in vitro susceptibility profiles of Candida isolates. Samples were obtained by swabbing lesions and intact oral mucosa for internal control, seeded on Sabouraud Dextrose and CHROMagar® Candida plates to assess colonization/infection and presumptive species identification; subsequently confirmed by matrix-assisted laser desorption/ionization time-of-flight (MALDITOF). Candida spp. prevalence was 36.8% and 18.2% in oral leukoplakia and oral lichen planus cases, respectively. Candida albicans was the sole species found in oral lichen planus lesions, n=2, 100%, and the most prevalent in oral leukoplakia, n=5, 76.4%. Among non-albicans Candida species in oral leukoplakia, C. parapsilosis (n=2, 25.5%) and C. tropicalis (n=1, 14.1%). Candida isolates, n=9, were susceptible to all tested antifungals. C. albicans was the most predominant species found in the studied lesions. Systemic and local factors showed no association in positive cases of oral lichen planus, but smoking and alcohol consumption may be associated with positive cases of oral leukoplakia, as well as the non-homogeneous clinical form. A possible predisposition to Candida colonization associated with epithelial dysplasia found in oral leukoplakia is suggested. The tested antifungal medications showed efficacy against the isolates.
Análise comparativa da temperatura gerada por diferentes designs de brocas em osteotomia para implantes dentários : influência da reutilização
(Universidade Federal do Espírito Santo, 2025-07-16) Batista, João Pedro Oliveira de; Ramos, Umberto Demoner ; https://orcid.org/0000-0002-3759-1364; http://lattes.cnpq.br/7171760362653486; https://orcid.org/0009-0006-7011-9156; http://lattes.cnpq.br/9326566521319765; Andrade, Valdir Cabral ; https://orcid.org/0000-0002-1680-2855; http://lattes.cnpq.br/8411428235547363; Borges Filho, Fausto Frizzera ; https://orcid.org/0000-0002-0027-6686; http://lattes.cnpq.br/1222141128228079
This study evaluated the influence of drill geometry and progressive reuse on heat generation during osteotomy for dental implant placement. Two drills from the same manufacturer were compared: the Epikut® (cylindrical design) and the Strong SW® (conical drill design), using polyurethane blocks simulating type III human bone density. Drilling was performed without irrigation, and thermal monitoring was conducted using infrared thermography. The Epikut® drills demonstrated thermal stability over up to 30 reuses, with no significant increase in final mean temperature (p = 0.197). For example, the Epikut 2.0 mm produced mean temperatures of 45.15 ± 0.39 °C (1-10 uses) and 44.87 ± 0.89 °C after 30 uses. Other Epikut drills (2.7 mm, 3.0 mm, and 3.3 mm) remained below 35°C on average. In contrast, the Strong SW® drills showed a progressive and statistically significant increase in temperature with the number of reuses (p < 0.001). The Strong SW 2.0 mm, for instance, increased from 30.93 ± 0.92 °C (1-10 uses) to 36.11 ± 6.43 °C after 30 uses. The Strong SW 3.05 mm rose from 17.71 ± 4.17 °C to 33.55 ± 5.34 °C. The results suggest that the tapered design of the Epikut® drill promotes better thermal dissipation and greater safety for reuse, while the cylindrical design of the Strong SW® poses a higher risk of bone overheating after multiple reuses. These findings highlight the importance of appropriate instrument selection and strict control over the number of uses to preserve bone viability and ensure successful osseointegration
Análise de alterações nucleares nas mucosas jugal, labial e lingual em indivíduos com epidermólise bolhosa residentes no Espírito Santo e correlações clínico-patológicas
(Universidade Federal do Espírito Santo, 2025-02-27) Badaró, Rebeca Ferreira; Souza, Letícia Nogueira da Gama de; https://orcid.org/0000-0001-6330-996X; http://lattes.cnpq.br/2797885632539769; Freitas, Vanessa Morais; Barroso, Danielle Resende Camisasca
Epidermolysis Bullosa (EB) is a severe genetic disorder characterized by the continuous formation of blisters on the skin and mucous membranes, potentially leading to significant structural alterations in the oral cavity. This study aimed to analyze nuclear aspects of cytotoxicity and mutagenicity in exfoliated cells from the buccal, labial, and lingual mucosa of patients with EB. Sociodemographic and clinical data were collected through physical examination and a standardized questionnaire. Exfoliated cells from the buccal, labial, and lingual mucosa were assessed for the frequency of micronuclei (MN), karyorrhexis (KR), karyolysis (KL), and pyknosis (PN). The Mann-Whitney and Kruskal-Wallis tests were used for statistical analysis. The study included 20 EB patients and 20 age- and sex-matched controls. A similar distribution was observed between males (40%) and females (60%), with a predominance of individuals ≤19 years old (65%). Quantitative analysis revealed a significant increase in KR and KL in EB patients compared to controls, particularly in the buccal (p=0.0002; p<0.0001) and labial mucosa (p=0.0005; p=0.0240). Additionally, MN frequency was higher in the EB group, especially in the buccal mucosa (p=0.0083). These findings indicate an increase in cytotoxic and mutagenic events in the oral mucosa of EB patients, suggesting a link between genomic instability and the disease. Cytological smear analysis may serve as a promising tool for the dental monitoring of these patients, particularly in severe cases
Análise histomorfométrica e da citotoxicidade de uma biocerâmica de fosfato de cálcio obtido a partir da casca de ovo de galinha para engenharia tecidual
(Universidade Federal do Espírito Santo, 2023-06-14) Nascimento Neto, Conrado Dias do Nascimento; Silva, Daniela Nascimento; http://lattes.cnpq.br/3613001852759565; https://orcid.org/0000-0002-2097-5169; http://lattes.cnpq.br/0930321951875182; Barroso, Danielle Resende Camisasca; http://lattes.cnpq.br/3989074593181674; Maia, Monica Diuana Calasans
Goal: To investigate the cytotoxicity and effect on tissue repair of a hydroxyapatite/dicalcium phosphate anhydrous (HA/DCPA) material obtained from chicken eggshell compared to the commercially available maxresorb® (MXR). Methods: Cytotoxicity was evaluated in fibroblasts (L cell, L-929) by the MTT test. Tissue repair was evaluated after grafting of biomaterials into critical-sized bone defects (CSDs) trephined in the calvarial bones of 24 Wistar rats. The animals were euthanized after 30, 60, and 90 days and the bone specimens containing the graft area were examined by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS) (n=3), and histologic and histomorphometric analyses (n=21). The percentages of newly formed bone, connective tissue, remaining biomaterial, and total tissue repair area were compared between groups using Student’s t-test and ANOVA (p≤0.05). Results: HA/DCPA did not exhibit any cytotoxicity. Histologically, the CSDs contained newly formed bone from the defect margins and from ossification centers interspersed throughout the biomaterials. At 30 days, animals in the HA/DCPA group had a larger total tissue repair area than those in the MXR group (p=0.047), due to preservation of newly formed bone, connective tissue, and remaining biomaterial within the CSDs. No differences were observed between the experimental groups regarding percentage of newly formed bone, connective tissue, and remaining biomaterial at the time points of observation (p>0.05). Conclusions: Chicken eggshell-derived HA/DCPA is devoid of cytotoxic potential and can induce new bone formation and complete tissue filling of critical-sized bone defects with a degree of biomaterial degradation to the same extent as MXR.
Associação entre o trauma dentário e a reabsorção cervical invasiva: uma revisão sistemática
(Universidade Federal do Espírito Santo, 2023-12-05) Minchio, Evelin Scarabelli; Lima, Thiago Farias Rocha; http://lattes.cnpq.br/3369191934450137; https://orcid.org/0009-0000-9426-2252; http://lattes.cnpq.br/4381255460386014; Kill, Kleber Borgo; Ribeiro, Francisco Carlos; http://lattes.cnpq.br/3815967685248682
Cervical invasive resorption (ICR) is a still largely misunderstood pathology that involves dentin, periodontium and may or may not involve the pulp. The biological mechanism associated with the occurrence of ICR is directly related to the integrity of the cementum, which provides root protection. This starts when this tissue suffers some damage or has a deficiency, which generates exposure of the root to clastic cells, which initiate root resorption. Many can be the causes that cause these cement defects, as well as multiple factors can be associated. Among the main predisposing factors, Dental Trauma stands out. The objective of this systematic review was to evaluate the relationship between invasive cervical resorption and the main predisposing factors, with emphasis on dental trauma as a single or associated agent. Searches were carried out in PubMed, Embase, Scopus, Web of Science, LILACS, Scielo and Google Scholar databases. Observational clinical studies were included whose sample consisted of patients affected by invasive cervical resorption, with no restriction regarding publication date or language. The methodological quality assessment instrument used to assess the included studies was the Joanna Briggs Institutute Critical Appraisal Checklist for Systematic Reviews and Research. A total of 6.484 articles were found, four of which were included in the qualitative analysis. In all studies, Dental Trauma was considered a relevant etiological factor for the occurrence of invasive cervical resorption, with a prevalence that varied between 27-33%, being evaluated as a single etiological factor or associated with other factors. The risk of bias in these studies was considered to be of low reliability, since 2 articles were evaluated with a high risk of bias (37.5% and 50%) and two others with a moderate risk of bias (both 62.5%). Although the studies presented have supported the relationship between dental trauma and the development of invasive cervical resorption, the literature on the subject is scarce and the studies evaluated present a high risk of bias. The need for further studies on the subject is highlighted so that this relationship can be established with greater reliability.
Atitude dos professores da rede municipal de ensino frente à situação de traumatismo dentário
(Universidade Federal do Espírito Santo, 2024-02-08) Santos, Pamela Barbosa dos; Miotto, Maria Helena Monteiro de Barros ; https://orcid.org/0000-0002-3227-7608; http://lattes.cnpq.br/4289442514763843; https://orcid.org/0000-0002-4155-7441; http://lattes.cnpq.br/8951452929618117; Sanglard, Luciana Faria ; https://orcid.org/0000-0002-2520-7062; http://lattes.cnpq.br/4718823259148176; Barcellos, Ludmilla Awad ; https://orcid.org/0000-0003-3732-9515; http://lattes.cnpq.br/7262427405068645
Objective: To evaluate the attitudes of teachers from the municipal education network of the Vitória City Hall in different dental trauma scenarios and associate them with socioeconomic, demographic, and functional variables. Material and Methods: A quantitative, cross-sectional, and probabilistic study was conducted. Data collection was carried out through self administered and validated questionnaires, addressing sociodemographic and functional information as well as knowledge about dental trauma. Correct or incorrect attitudes were assessed in three different scenarios. Statistical analyses included chi-square tests (p < 0.05), descriptive analyses, and frequency tables with numbers and percentages. A total of 292 teachers from 37 schools participated in the study. Results: Among the participants, 137 (46.9%) teachers had witnessed cases of dental trauma, with 94 (68.6%) of these cases occurring in the school environment. Additionally, 274 (93.8%) teachers had never received formal guidance on the subject. It was observed that teachers who received guidance on dental trauma in scenario 3 had a statistically significant association (p = 0.030) with a higher frequency of correct attitudes among those who had undergone training on the topic. Similarly, teachers who had experienced dental trauma situations showed a potentially significant association (p = 0.056) with correct attitudes. No statistically significant differences were observed concerning socioeconomic and sociodemographic variables. Conclusion: The scenario assessment revealed a significant prevalence of incorrect attitudes regarding dental avulsion cases among teachers. This underscores the urgent need to implement educational actions and training programs, as well as to include the topic in teacher education, aiming to prepare them to effectively handle such situations.
Avaliação da qualidade de vida associada a reabilitação com implantes dentários
(Universidade Federal do Espírito Santo, 2023-12-19) Bastos, Lívia Martins Cardoso; Miotto, Maria Helena Monteiro de Barros; http://lattes.cnpq.br/4289442514763843; https://orcid.org/0000-0001-5884-3535; http://lattes.cnpq.br/2019193618899264; Sanglard, Luciana Faria; http://lattes.cnpq.br/4718823259148176; Barcellos, Ludmilla Awad
The general objective of this study was to analyze the quality of life related to treatments with implant-supported prostheses in patients treated at postgraduate schools in Vitória and Vila Velha in the state of Espírito Santo, from November 2021 to March 2023. Initially, the impact on the quality of life of 319 patients in need of implant prostheses was evaluated and the possible associations between sociodemographic variables, use of removable prostheses, reason for seeking dental care and number of lost teeth. A questionnaire was used to define the sociodemographic and socioeconomic profile and with data on the number and location of missing teeth, use of prostheses and reason for seeking dental care. Data on patient treatment were collected from patient records and the Oral Health Impact Profile (OHIP-14) instrument was used to measure quality of life. To verify the associations between the independent variables and the dimensions assessed by the OHIP-14 instrument, the Fischer Exact Test was used and the significance level adopted was 5%. To assess the strength of the association between the independent variables and the OHIP-14 dimensions, the odds ratio (OR) was calculated and the confidence interval (CI) used was 95%. To analyze the effect of the combined dimensions, the Mantel-Haenszel test was used. The second stage of the study evaluated the quality of life of 160 patients before and after rehabilitation with prostheses. This is a prospective, uncontrolled, “before and after” longitudinal intervention study. Data collection was carried out by reapplication of the OHIP-14 via telephone 30 to 60 days after rehabilitation. Comparison of quality of life parameters before and after rehabilitation with implant-supported prostheses was carried out using the non-parametric Wilcoxon test. The predilection for impact was associated with female individuals, with low education, belonging to classes C and D/E, using removable dentures, who sought urgent care and who lost all their teeth. The number of individuals with an impact on quality of life before the proposed treatment was 216 (67.7%), and this number significantly reduced after implant treatment to 6 (3.8%).
Avaliação do conhecimento dos docentes de um município do Sudeste brasileiro acerca de traumatismos dentários
(Universidade Federal do Espírito Santo, 2022-09-15) Silva, Jéssica Giovani da; Miotto, Maria Helena Monteiro de Barros; https://orcid.org/0000-0002-3227-7608; http://lattes.cnpq.br/4289442514763843; https://orcid.org/0000-0002-3579-1514; http://lattes.cnpq.br/6687544461400139; Lima, Thiago Farias Rocha; http://lattes.cnpq.br/3369191934450137; Barcellos, Ludmilla Awad; https://orcid.org/0000-0003-3732-9515; http://lattes.cnpq.br/7262427405068645
Dental trauma are considered a public health problem and are the second leading cause of dental emergencies with the possibility of irreversible local damage, and the school environment hasthe highest occurrence, which gives teachers the responsibility to adopt the first steps in an attempt to prevent the installation of sequelae. Thus, we intend to evaluate the knowledge of teachers of the municipal school network of Brejetuba-ES, about dental trauma. For this purpose, an observational, quantitative and transversal study was conducted. The sample consisted of 117 teachers, distributed in rural and urban areas. Data collection was done through the application of questionnaires and scripts with images by means of the self-managed technique. The data treatment was done by means of frequency tables with number and percentage, and the analysis was done by means of the IBM SPSS 20 statistical package. The T-test and ANOVA were used to compare the number of correct answers with the independent variables. The results show a deficiency of knowledge in all the scenarios analyzed, with no statistically significant difference between the variables studied. The lack of preparation to deal with it immediately was generally absent, which enables and encourages the installation of sequelae and early dental losses that directly compromise quality of life. Health promotion actions for the dissemination of information are necessary, as well as the insertion of the theme in the curriculum during teacher training, in addition to continued training for those who are already working.
Avaliação do impacto da saúde bucal na qualidade de vida de uma população rural pomerana
(Universidade Federal do Espírito Santo, 2025-03-31) Maria, Lorrayne Cesario; Miotto, Maria Helena Monteiro de Barros; https://orcid.org/0000-0002-3227-7608; Sanglard, Luciana Faria; Barcellos, Ludmilla Awad
Studies dedicated to assessing the quality of life of the rural population and the community are scarce. Expanding research on Pomeranians is essential in order to contribute to the development of public policies that meet their specific needs. This study assessed the impact of oral health on quality of life, possible associations with sociodemographic variables, demand for dentures, dental status, type of access and reason for using dental services in a rural Pomeranian population. This is a cross-sectional study carried out with 300 descendants of Pomeranians, preferably of direct descent, who live in the district of Melgaço, municipality of Domingos Martins, state of Espírito Santo. Data was collected through face-to-face interviews at home, using the Oral Health Impact Profile - 14 instrument to assess quality of life and a structured questionnaire with the other study variables. The Fischer Exact and Mantel Haenszel tests were used for statistical analysis, and the odds ratio was calculated. The impact of oral health on quality of life was declared by 68 individuals (22.7%), with a higher prevalence in the following dimensions: psychological discomfort (13%), physical pain (12.3%) and psychological disability (12%). This impact was associated with individuals aged 41 or over, who had studied up to 12 years, who were non-white and who used the public health service or had no access to it. The absence of at least one tooth, the demand for dental prostheses and the use of dental services as a matter of urgency were factors that had an impact on the quality of life of 22.7% of these individuals.
Avaliação do impacto de problemas bucais na qualidade de vida de técnicos e enfermeiros hospitalares
(Universidade Federal do Espírito Santo, 2022-12-13) Barbosa, Julia Saraiva de Almeida; Rosetti, Elizabeth Pimentel; http://lattes.cnpq.br/2693147990422431; https://orcid.org/0000-0002-0450-5642; http://lattes.cnpq.br/1389786016400324; Barcellos, Ludmilla Awad; https://orcid.org/0000-0003-3732-9515; http://lattes.cnpq.br/7262427405068645; Barros, Liliana Aparecida Pimenta de; https://orcid.org/0000-0002-1649-3116; http://lattes.cnpq.br/8635277660080840
Objective: to evaluate the impact of oral problems on the quality of life of a hospital nursing team and its association with sociodemographic variables and stress. Methods: Cross-sectional study with a random sample of 111 nurses and nursing technicians from a university hospital. Three questionnaires were applied: Oral Health Impact Profile (OHIP-14), sociodemographic questionnaire and Bianchi Stress Scale. Fischer's exact test (p<0.05) found associations between each independent variable and the dimensions of the OHIP-14. To verify the strength of this association between event and exposure, the odds-ratio (OR) was calculated. To know the association between all the combined dimensions of the OHIP-14 (total score), with the independent variables, the Mantel-Haenzsel method was used, through the combined OR. Results: The prevalence of the impact of oral problems on quality of life was 51.4%. The dimensions with the greatest impact of oral problems were physical pain (37.8%) and psychological discomfort (35.1%), followed by physical disability (27.9%), psychological disability (26.1%), disability (18 .9%), functional limitation (15.3%) and social disability (11.7%). A higher frequency of oral health impact on quality of life was observed in individuals over 50 years of age (OR= 5.769, 95%CI= 1.806;18.431), single, widowed and divorced (OR= 2.396, 95%CI= 1.075;5.340), individuals with up to 12 years of schooling (OR= 2.766, 95%CI= 1.159;6.597), nursing technicians (OR= 4.073, 95%CI= 1.827;9.077) and individuals with up to 5 minimum wages (OR= 2.353, 95%CI = 1.080;5.127). In the relationship between stress and the impact of oral health, there was statistical significance in the dimensions disability (p=0.021), social disability (p=0.022) and psychological disability (p=0.045). Conclusion: Oral health conditions impact the quality of life of the hospital nursing team. Nursing technicians were more likely to have an impact on all dimensions that can be influenced by factors such as age, marital status, years of schooling, salary income and stress.
Avaliação por meio de tomografia computadorizada de feixe cônico dos resultados pós-cirúrgicos de dentes autotransplantados
(Universidade Federal do Espírito Santo, 2023-03-15) Intra, Tereza Jacy da Silva Almeida; Lima, Thiago Farias Rocha; http://lattes.cnpq.br/3369191934450137; https://orcid.org/0000-0003-1059-1978; http://lattes.cnpq.br/5176428120887979; Xavier, Karla Corrêa Barcelos; http://lattes.cnpq.br/0527980061772295; Mello, Paula Sampaio de; http://lattes.cnpq.br/8847767386354163
Autotransplantation may favor the treatment of children who have experienced trauma. Most of the success of self-transplanted teeth happens in the age group between 7 and 13 years old. Considering that at this age, the rehabilitation of these children is difficult, since most treatments would interfere with craniofacial growth and development, autotransplantation is highlighted and the scientific literature already proves this. In this study, after approval by the ethics and research committee, 23 patients who had already undergone autotransplantation treatment performed at the Dental Trauma Project of the Brazilian Association of Dentistry of Espírito Santo (ABO-ES) participated. All guardians signed the Free and Informed Consent Term (TCLE) to enable the evaluation through tomographic analysis. In all, 30 teeth were analyzed using Cone Beam Computed Tomography. All images, in DICOM format, were properly analyzed by three previously calibrated evaluators (one radiologist and two endodontists) using the Prexion Viewer program (Terarecon, San Mateo, CA, USA). The main post-surgical results considered were pulpal and periodontal repair. All teeth were premolars and 04 teeth were submitted to endodontic treatment. In 16 teeth the pulp chamber was completely obliterated, 06 teeth partially obliterated and 04 teeth with normal pulp chamber. 21 teeth with partially calcified canal and 02 with completely obliterated canal. 03 teeth with normal aspect and 01 tooth presented internal resorption. The periodontal space and lamina dura were preserved in 29 teeth and absent in only 01 tooth. Images of inflammatory resorption were observed in 09 teeth and 01 specimen showed substitutive resorption. 10 teeth had unchanged apical periodontium, 10 teeth had periapical lesions, 08 teeth had increased periodontal space and 15 teeth had apical resorption. Root development was complete in 24 teeth and incomplete in 06 teeth. When considering the follow-up of these individuals, these were divided into: 3-5 years, 5-10 years and for more than 10 years. However, when the data of the variables contained in the study and the follow-up time were crossed, no statistical significance was observed. Considering the results and analyses, it can be concluded that the self-transplanted teeth present favorable results regarding pulpal and periodontal repair, remaining viable and integrated to the new site, in all specimens.
Caracterização dos fatores dificultadores do diagnóstico precoce do câncer de boca por cirurgiões-dentistas do serviço público de saúde do Estado do Espírito Santo – um estudo transversal
(Universidade Federal do Espírito Santo, 2025-07-17) Martins, Bárbara Campo Dall’Orto; Almeida, Tahyná Duda Deps; https://orcid.org/0000-0002-5780-1576; http://lattes.cnpq.br/5705338964053484; Barros, Liliana Aparecida Pimenta de; https://orcid.org/0000-0002-1649-3116; http://lattes.cnpq.br/8635277660080840; https://orcid.org/0009-0001-0880-7752; http://lattes.cnpq.br/7874095033006385; Toporcov, Tatiana Natasha; https://orcid.org/0000-0002-8929-5137; http://lattes.cnpq.br/5345064895953228 ; Pigatti, Fernanda Mombrini; https://orcid.org/0000-0001-8495-8571; http://lattes.cnpq.br/8243371686189167
Oral cancer represents a serious public health issue in Brazil, characterized by high morbidity and mortality rates, largely due to late-stage diagnosis. Primary Health Care (PHC), as the preferred entry point to the Brazilian Unified Health System (SUS), plays a strategic role in the early detection of the disease, particularly through the work of dental surgeons. This cross-sectional study aimed to identify the main barriers to the early diagnosis of oral cancer within the PHC network in the state of Espírito Santo, Brazil. A structured questionnaire was applied to 248 dental surgeons, alongside an analysis of diagnostic support infrastructure data. The findings revealed low service resolvability, evidenced by the limited performance of biopsies among PHC professionals (16.13%), a high rate of insecurity in diagnosing potentially malignant lesions (64.5%), and lack of knowledge regarding institutional referral pathways. Among professionals who reported limited knowledge and low confidence in diagnosing oral potentially malignant disorders, 47.9% stated they did not feel capable of performing a biopsy (p < 0.001). These results suggest that limited practical training and structural deficiencies compromise the effectiveness of PHC, highlighting the need for integrated continuing education initiatives, expansion of diagnostic support networks, and stronger coordination across levels of care.
Caracterização sociodemográfica, clínica e itinerária do carcinoma escamocelular oral em um centro de referência do estado do Espírito Santo
(Universidade Federal do Espírito Santo, 2025-08-15) Guimarães, Mariana Barbosa ; Leitão, Águida Cristina Gomes Henriques; https://orcid.org/0000-0002-8591-3655 ; http://lattes.cnpq.br/2563401100488039; Barroso, Danielle Resende Camisasca; https://orcid.org/0000-0003-1193-2113 ; http://lattes.cnpq.br/3989074593181674; https://orcid.org/0009-0002-7378-980X ; http://lattes.cnpq.br/1829498964857800; Toporcov, Tatiana Natasha ; https://orcid.org/0000-0002-8929-5137 ; http://lattes.cnpq.br/5345064895953228; Esposti, Carolina Dutra Degli; https://orcid.org/0000-0001-8102-7771; http://lattes.cnpq.br/7465412734380334
O carcinoma escamocelular (CEC) é tipo histopatológico mais comum do câncer de boca, ocupando o 8º lugar em incidência no Brasil. O sítio mais acometido é a borda lateral de língua, causado principalmente pelo alto consumo de tabaco e álcool, e o seu diagnóstico tardio é uma das principais causas de morbimortalidade elevada entre a população. Este estudo visa analisar o perfil dos pacientes portadores do CEC oral numa população do Espírito Santo (ES), de acordo com suas características sociodemográficas, clínicas e itinerária. Trata-se de um estudo transversal, coletado através de prontuários de pacientes submetidos a tratamento para o CEC oral no período de 2015 a 2023 em um centro de referência. Análise descritiva, Teste de Qui quadrado e Exato de Fisher foram utilizadas para análise das variáveis. Intervalos de tempos foram definidos para a investigação itinerária, bem como serviço ofertado e completude dos dados. Foram obtidos 48 casos, predominantemente homens (n=33, 68,7%), idade avançada (42 a 95 anos, média 60,7), pardos (n=33, 68,7%), tabagistas (n=19, 39,5%) e etilistas (n=21, 43,7%), com ensino fundamental incompleto (n=15, 31,2%). A maioria (n=29, 51,7%) das lesões estavam em língua, ulceradas e nodulares (n=26, 54,1%; n=10, 20,8%). A cirurgia foi o tratamento mais usado (n=35, 72,9%), e o serviço público o mais ofertado na consulta inicial (n=44, 91,6%) e tratamento (n=47, 100%). O intervalo da detecção da lesão pelo paciente até procurar atendimento em saúde obteve mediana de 6 (de 1 a 48) meses. O intervalo até o diagnóstico obteve mediana de 0,3 (de 0 a 65,7) meses, e o intervalo até o início do tratamento foi de 1 (de 0 a 15,8) mês. Houve associação entre pardos (p=0,04) e hipótese clínica de CEC (p=0,04) com o menor período de intervalo do paciente (0 6m), além da associação entre estágios iniciais I e II e tratamento cirúrgico (p=0,04). O perfil dos pacientes diagnosticados com CEC no ES evidenciam um padrão clássico e demonstram a relevância do serviço público. Os intervalos de tempo atendem a lei brasileira e seu estudo pode direcionar para políticas preventivas
Comparação Clínicopatológica e da Expressão da Citoqueratina-10 Entre Liquen Plano e Lesão Liquenoide Oral
(Universidade Federal do Espírito Santo, 2024-03-07) Moreira, Milena Duarte; Barroso, Danielle Resende Camisasca; https://orcid.org/0000-0003-1193-2113; http://lattes.cnpq.br/3989074593181674; https://orcid.org/0009-0002-2952-7474; http://lattes.cnpq.br/0214358029056111; Barros, Liliana Aparecida Pimenta de; https://orcid.org/0000-0002-1649-3116; http://lattes.cnpq.br/8635277660080840; Silva Júnior, José de Assis; https://orcid.org/; http://lattes.cnpq.br/9737483962693792
Background: Oral lichen planus malignant transformation potential has been largely debated. Cytokeratin-10 is suggested as an indicator of a dysplastic epithelium and can be used to assess malignant progression in oral potentially malignant disorders. This study aimed to compare clinical, histopathological features and immunostaining for cytokeratin-10 between oral lichen planus and oral lichenoid lesion. Methods: Retrospective longitudinal study comparing lichen planus and oral lichenoid lesions diagnosed at the Oral Pathological Anatomy Service, analysing socio-demographic, clinicopathological data and CK-10 expression. Chi-Square, Fisher's exact test and Mann-Whitney or Student's ttests were used, when appropriate; and p-values <.05 were considered significant. Results: A total of 23 lichen planus and 23 lichenoid lesions were included. There was an association between oral lichen planus and symptomatology (p=0.031). The buccal mucosa was the most affected site in both groups, 20 cases (87.0%) in lichen planus, and 16 cases (69.6%) in oral lichenoid lesion. Bilateral (p<0.001) striae (p=0.004) are more characteristic of oral lichen planus. There was an association of oral lichen planus with degeneration of the basal layer (p=0.049), as well as with mild epithelial dysplasia (p<0.001). Cytokeratin-10 immunostaining was similar between groups. Conclusion: A continuous follow-up is necessary to identify different patterns of malignant transformation between groups of lesions, as well as a comparison with lesions with a higher malignant transformation rate.
Cortisol salivar como biomarcador do estresse e sua correlação com a condição bucal em uma equipe de enfermagem hospitalar
(Universidade Federal do Espírito Santo, 2023-12-14) Alves, Alessandra Arthuso; Rosetti, Elizabeth Pimentel; http://lattes.cnpq.br/2693147990422431; https://orcid.org/0000-0002-8829-7739; http://lattes.cnpq.br/7597440818800179; Figueiredo, Luciene Cristina de; Carvalho, Raquel Baroni de; https://orcid.org/0000000185223577; http://lattes.cnpq.br/5266889552348216
Background: Occupational stress represents a significant cause of illness among nursing professionals. The primary hormonal system linked to stress is the hypothalamus-pituitary-adrenal axis, where cortisol synthesis and release occur. Oral cavity tissues contain receptors for glucocorticoids that respond to chronic cortisol exposure. Aim: To investigate salivary cortisol levels in a hospital nursing team and assess their correlation with clinical oral conditions. Methods: This is a cross-sectional analytical epidemiological study conducted on 46 nursing professionals from a university hospital in Espírito Santo. Salivary cortisol collection was performed using a Salivette® kit, and analyses were conducted using ultra-high-performance liquid chromatography and tandem mass spectrometry. Unstimulated salivary flow was collected through sialometry, and xerostomia was assessed using the Xerostomia Inventory (SXI) questionnaire. Clinical examinations included the evaluation of dental caries using the DMFT index and periodontal assessment. Occupational stress was assessed using the Job Stress Scale (JSS). Results: In our sample, 54.35% of participants had normal cortisol levels, and 45.65% had low cortisol levels. Xerostomia was present in almost all participants (93.48%), and 82.61% had normal salivary flow. The DMFT index in the sample was 13.1, and the prevalence of periodontitis was 63.04%. A significant association was found between low cortisol levels, xerostomia, and the JSS. High-demand job tasks were found to have 23.9 times higher odds of presenting low cortisol levels. Additionally, xerostomic individuals showed a higher average in the index of decayed, missing, and filled teeth. No significant association was found between cortisol and salivary flow, dental caries or periodontal condition. Conclusion: Low salivary cortisol levels were associated with chronic stress and high job demands. Low cortisol levels were also associated with the presence of xerostomia, which was consequently related to higher rates of decayed, missing, and filled teeth. No association was found between cortisol levels and periodontal disease.
Desenvolvimento De Um Novo Dispositivo De Posicionamento Radiográfico Para A Avaliação De Implantes Dentários
(Universidade Federal do Espírito Santo, 2024-01-25) Bonadiman, Eduarda Alberti; Vaz, Sergio Lins de Azevedo ; https://orcid.org/0000-0001-5578-5309; http://lattes.cnpq.br/0891895879748603; https://orcid.org/0000-0003-1454-5549; http://lattes.cnpq.br/0988085902471867; Vaz, Sergio Lins de Azevedo ; https://orcid.org/0000-0001-5578-5309; http://lattes.cnpq.br/0891895879748603; Ramos, Umberto Demoner ; https://orcid.org/0000-0002-3759-1364; http://lattes.cnpq.br/7171760362653486; Leite, André Ferreira ; https://orcid.org/0000-0002-7803-4740; http://lattes.cnpq.br/7275660736054053
This dissertation is composed of two studies. The first aimed to develop an adapter for the Cone Indicator radiographic film-holder, aiming to generate sharpener and more geometrically accurate images of dental implants. To achieve these goals, an additional rod and a rectangular trapezoid were designed in the SketchUp software and 3D printed. Implants with internal conical connection were installed in the central incisor region of 19 maxilla prototypes. Five dentists obtained 285 digital periapical radiographs using three different filmholders: Cone indicator, Rinn XCP and modified Cone Indicator. Then, they evaluated the implants threads sharpness and the implants radiographic dimensions in ImageJ software. The Friedman with post-hoc Durbin-Conover and MANOVA with post-hoc Tukey tests were used (α = 5%). Mesial threads were sharpener for the modified Cone Indicator than for the Cone Indicator film-holder (p<0.05). The modified Cone Indicator resulted in a smaller difference between the radiographic and the real implant diameter than the Rinn XCP and the Cone Indicator film-holders (p<0.05). In conclusion, the modified Cone Indicator filmholder resulted in radiographs of dental implants with greater sharpness and greater geometric accuracy. The second study set out to evaluate the accuracy of the modified Cone Indicator film-holder for detecting misfits at the abutmentprosthesis interface. A ceramic copping was made and coupled to the implants installed in the first study (20 jaw prototypes). Misfits of 50, 100 and 150 μm were simulated by interposing 1, 2 or 3 50-μm-thick polyester strips, respectively, positioned at the abutment-prosthesis interface; the absence of the strip represented the control group. An independent operator obtained 180 digital radiographs using the 3 film-holders tested in the first study. One radiologist, 1 prosthodontist and 1 general practitioner evaluated the images. The area under ROC curves (Az) were calculated and subjected to repeated measures ANOVA with post-hoc Tukey (α = 5%). No statistically significant differences among the three film-holders were found (p=0.381). In conclusion, the modified Cone Indicator film-holder had similar accuracy than other film-holders for detecting misfits at the abutment-prosthesis interface.
Detecção de desajustes na interface abutment-prótese: implicações da técnica radiográfica e da magnitude do desajuste na região estética
(Universidade Federal do Espírito Santo, 2023-03-09) Oliveira, Vanessa Pacheco de; Vaz, Sergio Lins de Azevedo; https://orcid.org/0000000155785309; http://lattes.cnpq.br/0891895879748603; http://lattes.cnpq.br/4818381330530030; Rebello, Iêda Margarida Crusoé Rocha; https://orcid.org/0000-0002-4956-0856; http://lattes.cnpq.br/1791043459642041; Pacheco, Maria Christina Thomé; https://orcid.org/0009-0004-5835-9670; http://lattes.cnpq.br/4000725435462305
Misfits in the abutment-prosthesis interface represent a setback in the rehabilitation treatment with dental implants. Periapical radiographs are used as an auxiliary method for assessing misfits at the abutment-prosthesis interface; however, the evidence supporting the use of this diagnostic method is restricted to studies of low to moderate quality. The aim of this in vitro study was to compare the accuracy of 3 periapical radiographic techniques in detecting misfits at the abutment-prosthesis interface in the esthetic region and to assess whether the magnitude of the misfit influences the diagnosis. For this, 15 implants with an internal conical connection were installed in the central incisor region in polyamide maxillae and copings for customized cemented crowns were made in ceramic using a CAD/CAM system. Misfits of 50, 100 and 150 μm were simulated by interposing 1, 2 or 3 polyester strips of 50 μm thickness, respectively, positioned at the abutment-prosthesis interface; the absence of the strip represented the control group. Digital radiographs were obtained using positioners for the following periapical techniques: bisecting (PTB), parallelism (PTP) and modified parallelism (PTM). A total of 180 digital radiographs were evaluated by 2 radiologists and 1 prosthodontist. The values of the area under the receiver operating characteristic curve (Az) were submitted to the Friedman test with post-hoc Durbin-Conover (α = 5%). Statistically significant differences were found (χ² = 22.0; p < 0.05). There was a statistical difference (p < 0.05) between the PTP (Az = 0.873) and PTB (Az = 0.753) techniques for magnitude 50 μm, with the PTP being more accurate. Larger magnitudes showed greater accuracy compared to smaller magnitudes (p < 0.05). In the technical and magnitude interactions, all comparisons had statistical differences (p < 0.05), except for PTP magnitude 100 μm (Az = 0.976) and PTM magnitude 150 μm (Az = 0.998). It was concluded that PTP was more accurate than PTB to detect misfits of 50 µm at the abutmentprosthesis interface and that larger misfits resulted in more accurate diagnoses regardless of the technique used.
Efeito da fotobiomodulação na peridontite experimental de camundongos hipercolesterolêmicos Apoe knockout
(Universidade Federal do Espírito Santo, 2023-08-21) Ribeiro, Isadora Martins; Campagnaro, Bianca Prandi; https://orcid.org/0000-0002-9023-4892; http://lattes.cnpq.br/6847063606394701; Meyrelles, Silvana dos Santos ; https://orcid.org/0000-0003-0167-4093 ; http://lattes.cnpq.br/7731215198101947; https://orcid.org/0000-0003-1008-1724; http://lattes.cnpq.br/4926826167047170; Ramos, Umberto Demoner; https://orcid.org/0000-0002-3759-1364; http://lattes.cnpq.br/7171760362653486; Tavares, Marcella Porto; https://orcid.org/0000-0003-4234-9721; http://lattes.cnpq.br/0850829266775500; Silva, Daniela Nascimento; https://orcid.org/0000-0003-0145-2247; http://lattes.cnpq.br/3613001852759565
Photobiomodulation therapy (PBM) has attracted special attention and can lead to positive physiological responses or inhibitory biological effects. PBM has been studied mainly in the treatment of Periodontal Disease (PD), which is one of the most common inflammatory conditions. The periodontitis-systemic disease relationship constitutes an important part of clinical periodontal research. Cardiovascular diseases, which are an example of diseases worsened by PD, can be caused by hypercholesterolemia, which has been proposed as a possible link between chronic periodontal inflammation and atherosclerosis. Therefore, this study seeks to evaluate the effects of photobiomodulation by infrared irradiation (NIR-PBM) on oxidative stress and inflammatory activity in the knockout animal model (ApoE-/-) with PD caused by ligation. ApoE-/- mice aged 16 weeks and 25-30 g were used. Induction of periodontitis by ligation was performed over a period of four weeks. The animals were divided into three experimental groups: ApoEC (n=6-8), which did not receive intervention; ApoEP (n=6-8), with periodontitis caused; and ApoEP+PBM (n=6-8), with periodontitis caused and NIR-PBM with an energy density of 6 J per session (808 nm, continuous wave, ø ~ 3 mm2, 100 mW) for 60 seconds for seven consecutive days. Alveolar bone loss was assessed using scanning electron microscopy of the mandible; the quantification of reactive oxygen species (ROS) by flow cytometry; plasma cholesterol levels; inflammatory activity (myeloperoxidase levels) and plasma oxidative stress (lipid peroxidation) through biochemical assays. The success of PD caused by ligation was due to the significant alveolar bone loss in the ApoEP group compared with the ApoEC group. Periodontitis increased plasma cholesterol levels in the ApoEP group, compared to ApoEC. Animals in the ApoEP group showed higher levels of myeloperoxidase (MPO) when compared to the ApoEC group. The levels of superoxide anion and hydrogen peroxide are different when compared to ApoEP and ApoEC, showing an increase in ROS production in animals with periodontitis. The ApoEP+PBM group presented reduced levels when compared to animals in the ApoEP group, and the ApoEC group presented lower levels of hydrogen peroxide than the ApoEP+PBM group. Higher levels of lipid peroxidation were presented in the ApoEP group than in the ApoEC group and animals that received NIR-PBM had lower levels than untreated animals, implying that periodontitis increases oxidative stress, but PBM treatment decreases it. these levels. We conclude that in hypercholesterolemic animals, NIR-PBM is effective in reducing systemic disruptions involved in the progression and worsening of periodontal disease. Furthermore, further studies with longer evaluation times are needed to elucidate the effects of PBM on experimental periodontitis related to hypercholesterolemia

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