Estudo de biomarcadores relacionados à agressividade e invasividade em carcinoma de células escamosas oral
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Data
2015-11-20
Autores
Callegari, Eline Manhães Reid
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Universidade Federal do Espírito Santo
Resumo
In tumorigenesis process, laminin-332 performs multiple biologic effects by γ2 chain, and MMP-9 acts disrupting extracellular components. We aimed to assess the molecular profile of γ2 chain and MMP-9 in leukoplakias oral high-risk, carcinoma in situ (CIS) and oral invasive carcinoma cell squamous (OSCC) and establish possible associations with clinicopathologic features. γ2 chain and MMP-9 expression were assessed by immunohistochemistry in 10 patients with high-risk malignancy lesions and 26 cases of invasive OSCC. The immunostaining of γ2 chain in high-risk lesions showed most cases with a continuous basement membrane, on the other hand the majority of invasive OSCC had a discontinuous membrane or absence. OSCC stromal cells showed a higher presence of MMP-9 compared to cases of high-risk lesions. The association between clinical and expression profile demonstrated that smokers with invasive OSCC had a higher expression of γ2 chain in epithelium and MMP-9 in invasive fronts. A higher expression of MMP-9 in stromal cells was associated with male patients, older than 60 years and diagnosed with invasive OSCC when compared with high-risk lesions. Our results indicate an association between clinical and microscopic features in oral lesions with high malignant potential and oral carcinomas, with a progressive change in γ2 chain and MMP-9 expression during tumorigenesis.
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Palavras-chave
Laminin-332 , Y2 Chain , Matrix metalloproteinase-9 , Oral squamous cell carcinoma , Laminina-332 , Cadeia γ2 , Laminina , Metaloproteinase 9 da matriz , Carcinoma de células escamosas oral
Citação
CALLEGARI, Eline Manhães Reid. Estudo de biomarcadores relacionados à agressividade e invasividade em carcinoma de células escamosas oral. 2015. 126 f. Dissertação (Mestrado em Clínica Odontológica) - Programa de Pós-Graduação em Clínica Odontológica, Universidade Federal do Espírito Santo, Vitória, 2015.