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Título: Influence of renal denervation on blood pressure, sodium and water excretion in acute total obstructive apnea in rats
Autor(es): Franquini, Joao Vicente Maggioni
Medeiros, Ana Raquel Santos de
Andrade, Tadeu Uggere de
Araújo, Maria Teresa Martins de
Moyses, Margareth Ribeiro
Abreu, Gláucia Rodrigues de
Vasquez, Elisardo C. (Elisardo Corral)
Bissoli, Nazaré Souza
Palavras-chave: Apnéia do sono tipo obstrutiva
Pressão arterial
Renal nerve
Sleep Apnea, obstructive
Blood Pressure
Data do documento: Fev-2009
Citação: FRANQUINI, J. V. M. et al. Influence of renal denervation on blood pressure, sodium and water excretion in acute total obstructive apnea in rats. Braz J Med Biol Res, Ribeirão Preto, v. 42, n. 2, p. 214-219, fev. 2009. Disponível em: <>. Acesso em: 24 fev. 2011.
Resumo: Obstructive apnea (OA) can exert significant effects on renal sympathetic nerve activity (RSNA) and hemodynamic parameters. The present study focuses on the modulatory actions of RSNA on OA-induced sodium and water retention. The experiments were performed in renal-denervated rats (D; N = 9), which were compared to sham (S; N = 9) rats. Mean arterial pressure (MAP) and heart rate (HR) were assessed via an intrafemoral catheter. A catheter was inserted into the bladder for urinary measurements. OA episodes were induced via occlusion of the catheter inserted into the trachea. After an equilibration period, OA was induced for 20 s every 2 min and the changes in urine, MAP, HR and RSNA were recorded. Renal denervation did not alter resting MAP (S: 113 ± 4 vs D: 115 ± 4 mmHg) or HR (S: 340 ± 12 vs D: 368 ± 11 bpm). An OA episode resulted in decreased HR and MAP in both groups, but D rats showed exacerbated hypotension and attenuated bradycardia (S: -12 ± 1 mmHg and -16 ± 2 bpm vs D: -16 ± 1 mmHg and 9 ± 2 bpm; P < 0.01). The basal urinary parameters did not change during or after OA in S rats. However, D rats showed significant increases both during and after OA. Renal sympathetic nerve activity in S rats increased (34 ± 9%) during apnea episodes. These results indicate that renal denervation induces elevations of sodium content and urine volume and alters bradycardia and hypotension patterns during total OA in unconscious rats.
ISSN: 1678-4510
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