Mestrado Profissional em Clínica Odontológica

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Análise Comparativa entre Leucoplasia Oral e Leucoplasia Verrucosa Proliferativa (LVP) e Caracterização da Imunoexpressão da Citoqueratina-19 na LVP
(Universidade Federal do Espírito Santo, 2020-05-15) Fonseca, Emanuely Ronconi da; Barroso, Danielle Resende Camisasca; https://orcid.org/; http://lattes.cnpq.br/3989074593181674; https://orcid.org/; http://lattes.cnpq.br/; Barros, Liliana Aparecida Pimenta de; https://orcid.org/; http://lattes.cnpq.br/8635277660080840; Gouvea, Sonia Alves; https://orcid.org/000000015180471X; http://lattes.cnpq.br/7268228122543743
Objectives: To survey and review the cases diagnosed as oral leukoplakia (OL) at the UFES Department of Oral Pathological Anatomy, from 2009 to 2017, describe the clinical and socio-demographic histopathological characteristics, apply the criteria for pro
Análise histopatológica de lesões odontogênicas císticas dos maxilares antes e após descompressão cirúrgica
(Universidade Federal do Espírito Santo, 2016-12-15) Simão, Niverso Rodrigues; Velloso, Tânia Regina Grão; Silva, Daniela Nascimento; Bertollo, Rossiene Motta; Barroso, Danielle Resende Camisasca
Introduction: A conservative approach for the treatment of large jaws cysts is the surgical decompression that can promote the reduction in intracystic pressure, and consequent reduction of the lesion and possible histopathological changes of the epithelial lining and fibrous capsule. Objective: Assessing the histological changes of the cyst lining of odontogenic cystlike lesions before and after decompression. Methods: The authors was performed a retrospective cohort study using histological data records and slides of cystic lesions underwent surgical decompression of patients treated in the discipline of Oral and Maxillofacial Surgery II and Oral Diagnosis Center of UFES between July / 2010 and July / 2016. Clinical and demographic data of patients were obtained and the histopathological changes of the epithelial lining of cysts underwent surgical decompression analyzed with the aid of Binocular Microscope Primo Star (Carl Zeiss). The data were compared using the McNemar test (p-value <0.05). Results: The sample included 10 patients and 11 cystic lesions, which are more prevalent in males (54.55%), with a mean age of 31.1 years and time of decompression on average 12.7 months. There was agreement on the final diagnosis with the initial diagnosis in 9 lesions (81.81%). After decompression some changes cystic capsule were significant as compared to the before decompression aspect: intense inflammation development (p = 0.0468), the distribution of inflammation focal (p = 0.04364), location of the inflammatory infiltrate subepithelial (p = 0.02334), justaepitelial (p = 0.04123) and perivascular (p = 0.04364). Conclusion: There was agreement between the initial and the final diagnosis in most lesions. Surgical decompression increase the intensity inflammation in the capsule and shows a tendency to increase the thickness of the epithelial lining of the cystic lesions.
Análise imuno-histoquímica do colágeno tipo I em carcinoma de células escamosas orais e suas lesões precursoras
(Universidade Federal do Espírito Santo, 2017-03-09) Fanchiotti, Renata Escapini; Barros, Liliana Aparecida Pimenta de; Souza, Letícia Nogueira da Gama de; Barroso, Danielle Resende Camisasca; Pacheco, Marcos da Silva
Squamous cell carcinoma (SCC) is the most common cancer of the mouth, and is still associated with high mortality rates. Besides the evaluation of the clinical aspects, it is fundamental to perform a more accurate analysis of the molecular profile to better understand its biological behavior. Type I collagen is one of the main components of the extracellular matrix (ECM) and has been associated with the process of tumorigenesis by participating in events such as angiogenesis and metastasis. The present study performed an immunohistochemical analysis of the type I collagen profile in lesions diagnosed by the Department of Oral Pathology of the Dental School / UFES. The groups evaluated were: 10 cases of low risk lesions; 10 cases of high risk of malignancy and 30 cases of SCC. Also, associations were established between the markers and the clinical profile of the patient and the tumor. Our findings showed that men were the most affected in the lesions at high risk (60%) and SCC (86.6%), while women represented the majority in low risk lesions (80%). In relation to the affected sites, the jugal mucosa was the most frequent in the low risk lesions (50%), and the tongue in lesions of high risk (60%) and SCC (43.3%). As for the profile of type I collagen, the fibers were moderately irregular (C ++) and strongly marked. In the low risk lesions, the three types of fiber disposition were observed, and with weak marking; And those at high risk, the fibers were fine, regular and markedly strong. When the association between clinical and microscopic findings was found, it was possible to observe that patients smokers with SCC, the fiber pattern was irregular (P = 0.04) and strong marking (P = 0.02) compared to smokers, but diagnosed with lesions Low or high risk. Our findings suggest associations between clinical and microscopic aspects regarding the pattern of deposition of type I collagen during the alterations that occur in the oral mucosa in the process of malignant transformation.
Caracterização da expressão molecular da podoplanina e do Ki-67 nas displasias epiteliais e carcinomas de células escamosas orais : análise da transformação maligna
(Universidade Federal do Espírito Santo, 2015-12-18) Ribeiro, Fabiano de Azevedo; Souza, Leticia Nogueira da Gama de; Barros, Liliana Aparecida Pimenta de; Barroso, Danielle Resende Camisasca; Lourenço, Simone de Queiroz Chaves
Introduction: Oral squamous cell carcinoma (OSCC) is the most common malignancy in the oral cavity and its development involves a series of molecular mechanisms and may be preceded by oral potentially malignant disorders (OPMDs). Biomarkers expressed on the cell proliferation phase and involved in the invasiveness may lead to a better understanding of the carcinogenesis process. Objectives: To characterize the Ki-67 expression and D2-40 in OPDM and OSCC and their clinically healthy margins and confront the histopathological degrees and clinicopathological data from these lesions. Methods: In this cross-sectional study, we evaluated 25 OPDM, 10 OSCC and their perilesional tissues from May-2013 to July-2014 in the Oral Diagnosis Center. The morphometric alterations were evaluated in OPDM and OSCC by hematoxylin-eosin method and the expression of Ki-67 and podoplanin, qualitatively and quantitatively, by immunohistochemistry. Results: For the group of OPDM, most lesions showed no dysplastic changes on its margins, already in OSCC, 50% had severe OED and 20% moderate and 30% mild OED. In immunohistochemical analysis, compared the lesions and their perilesional tissues, Ki-67 showed a difference in OPDM (p = 0.016) between lesions OPDM and OSCC(p=0.006) and between perilesional tissue and peritumoral tissue (p=0.001). There was a direct relationship between higher degree of OED and greater expression of Ki-67 in OPDM (p=0.010) and its peritumoral tissues (p=0.022). The podoplanin showed higher expression rate in the lesions themselves than in their perilesional and peritumoral tissues, although not significantly different. There was a direct relationship (p=0.001) between severity of OED and expression of podoplanin in OPDM lesions and positive correlation between expression of Ki-67 and podoplanin in OSCC lesions(p=0.000). Conclusions: It was found a gradual increase in ascending order of the expression of molecular markers studied in perilesional tissue, OPDM, peritumoral tissues and OSCC. Besides the significant correlation between cell proliferation and the degree of oral epithelial dysplasia, and the degree of differentiation of OSCC, suggesting Ki-67 as an additional criterion for determine the severity of OPDM. The positive correlation between Ki-67 and D2-40 in OSCC points them as prognostic biomarkers and therapies targeted against cancer. Further studies may reveal a better participation of podoplanin in carcinogenesis.
Critérios para classificação e análise clínico- patológica comparativa entre líquen plano oral, lesões de aspecto liquenoide e leucoplasia verrucosa proliferativa em cavidade oral
(Universidade Federal do Espírito Santo, 2019-09-12) Miguel, Fernanda Cardoso Doyle Maia; Barroso, Danielle Resende Camisasca; https://orcid.org/0000-0003-1193-2113; http://lattes.cnpq.br/3989074593181674; https://orcid.org/0009-0007-3118-7727; http://lattes.cnpq.br/; Souza, Leticia Nogueira da Gama de; https://orcid.org/0000-0001-6330-996X; http://lattes.cnpq.br/2797885632539769; Velloso, Tania Regina Grao; https://orcid.org/0000-0001-6865-7955; http://lattes.cnpq.br/6427157237870625
Lichen planus is a mucocutaneos disease of unknow etiology and when it is in the oral cavity, it is named oral lichen planus (OLP). Early diagnosis and follow-up are necessary due to the potential for malignant transformation of these lesions and differential diagnosis with other lesions, such as leukoplakia and proliferative verrucous leukoplakia (PVL). Objective: To survey and review cases of OLP and leukoplakia, as well as to compare sociodemographic and clinicopathologic features among OLP, oral lichenoid lesion (OLL) and PVL. Method: A longitudinal and observational study was perfomed in which oral leukoplakia and OLP obtained from the UFES Oral Pathology database from 2009 to 2016 were reclassified into OLP, OLL, lichenoids reactions (LR) and PVL. Sociodemographic and clinicopathologic data were collected, and lesions compared using the chi-square or Fisher’s exact test. For data analysis, P values0,05 were considered significant. Results: The population consisted of 223 cases, among which 74 were OLP cases and 151 leukoplakia cases. After classification, according to criteria proposed in the study, 15 cases of OLP, 15 OLL, 2 LR and 11 PVL were evaluated. Maximum follow-up period was 102 months. OLP and LVP ocurred significantly more in women than OLL. Wickham striae (p
Estudo comparativo das anomalias dentárias em crianças portadoras e não portadoras da síndrome de Down
(Universidade Federal do Espírito Santo, 2017-09-29) Ramos, Ingrid Tigre; Gomes, Ana Maria Martins; Barroso, Danielle Resende Camisasca; Barros, Liliana Aparecida Pimenta de; Vaz, Sergio Lins de Azevedo; Velloso, Tânia Regina Grão
Introduction: The awareness of the dental characteristics associated with Down syndrome (DS) is fundamental to improve the quality of the dental service offered to these patients. Objective: Verify the types of systemic alterations present in children with DS; to investigate dental and jaw abnormalities, and the dental maturation stage in these children, comparing the results with a group of nonsyndromic children. Material and methods: The sample consisted of 93 panoramic radiographic exams, of which 31 were children with DS, who constituted the experimental group (EG), and 62 non-syndromic children that composed the control group (CG), aged 6-12 years. The variables studied were: systemic alterations (hypothyroidism, heart disease, alterations in airways, others), being evaluated only in the EG; dental anomalies (presence, absence, type and location), jaw abnormalities (presence, absence, type and location) and dental maturation stage, according to the Demirjian’s method. To verify the association of the variables, the chi-square statistical test was performed, considering values of p<0.05. Results: Out of the study population, 74% (n=23) of the EG presented some kind of systemic alteration (p<0.0001), being the most commonly found alterations in airways (45%; n=14). Dental anomalies were present in 74% (n=23) cases in EG and in 24% (n=16) in CG (p<0.0001), with a higher prevalence in EG for: hypodontia (p<0.0001), taurodontism (p=0.002) and microdontia (p=0.002). In EG, 69,6% (n=16) of dental anomalies were located in maxilla and mandible simultaneously (p <0.0001) and 65% (n=15) concomitantly in anterior and posterior regions (p=0.003). No jaw abnormalities were observed in EG, and in CG were observed in 6 (9%) patients (p=0.17). There was no statistically significant difference in the maturation stage between the groups. Conclusion: DS children have a high incidence of systemic alterations and, when compared to non-syndromic children, have a greater number of dental anomalies.

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