Ciências Fisiológicas

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http://repositorio.ufes.br/handle/10/17570
Programa de Pós-Graduação em Ciências Fisiológicas

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Navegando Ciências Fisiológicas por Assunto "Ácido elágico"

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    Efeito protetor do ácido elágico sobre a reatividade vascular e parâmetros morfofuncionais da aorta de ratos expostos por trinta dias ao cloreto de cádmio
    (Universidade Federal do Espírito Santo, 2025-08-29) Simões, Rakel Passos; Vassallo, Dalton Valentim; https://orcid.org/0000-0002-4463-4174; http://lattes.cnpq.br/7749285591179880; Padilha, Alessandra Simão ; https://orcid.org/0000-0002-9585-1347; http://lattes.cnpq.br/7658998034219799; https://orcid.org/0000-0003-0027-8128; http://lattes.cnpq.br/1703421305699091; Nunes, Karolini Zuqui ; https://orcid.org/0000-0003-3433-4925; http://lattes.cnpq.br/6888896554912256; Batista, Priscila Rossi de; https://orcid.org/0000-0001-5850-0989; http://lattes.cnpq.br/9629149780640340; Pereira, Camila Almenara Cruz ; https://orcid.org/0000-0001-7889-4161; http://lattes.cnpq.br/3103606418826712; Abreu, Glaucia Rodrigues de; https://orcid.org/0009-0008-8772-8470; http://lattes.cnpq.br/0229590907405570
    Cadmium (Cd) is a toxic heavy metal widely present in the environment, and its chronic exposure is associated with several deleterious effects on the cardiovascular system, including arterial hypertension and endothelial dysfunction. Ellagic acid (EA), a natural polyphenol with antioxidant, anti inflammatory, and chelating properties, has been proposed as a potential vascular protective agent. This study investigated the effects of EA on cardiovascular alterations induced by subchronic exposure to CdCl₂ (100 ppm for 30 days) in Wistar rats. Animals were divided into four experimental groups: Control (Ct), Cd, EA, and Cd+EA. Cd was administered via drinking water, and EA was given by gavage (30 mg/kg/day). Systolic blood pressure (SBP) was monitored weekly using tail-cuff plethysmography. At the end of the protocol, blood Cd concentration was consistent with levels observed in human occupational exposure (31.15 ± 2.8 µg/L). To assess vascular function, thoracic aortic rings were mounted in organ baths and subjected to protocols with phenylephrine, acetylcholine (ACh), and sodium nitroprusside (SNP), with or without endothelium, and in the presence of inhibitors (L-NAME, apocynin, catalase, allopurinol, and SOD). Cd exposure reduced body weight, increased SBP, enhanced vascular reactivity to phenylephrine, and impaired endothelium dependent relaxation, effects associated with reduced nitric oxide (NO) bioavailability and increased reactive oxygen species (ROS) production. Increased collagen deposition and endothelial cell damage were also observed. EA treatment prevented these changes, restoring endothelial function, normalizing vascular tone, and preserving collagen content and endothelial cell integrity. These findings indicate that EA exerts a significant protective effect against Cd-induced vascular toxicity and appears promising as a functional agent for the prevention of cardiovascular diseases
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    Efeitos do ácido elágico sobre a reatividade vascular em artérias de resistentes de ratas hipertensas e ovariectomizadas
    (Universidade Federal do Espírito Santo, 2019-08-23) Silva, Fabricio Braganca da; Abreu, Glaucia Rodrigues de; https://orcid.org/0009-0008-8772-8470; http://lattes.cnpq.br/0229590907405570; https://orcid.org/; http://lattes.cnpq.br/3532755171099760; Mill, Jose Geraldo; https://orcid.org/000000020987368X; http://lattes.cnpq.br/2497419234600362; Mauad, Helder; https://orcid.org/0000-0001-9694-2593; http://lattes.cnpq.br/4554702077415995; Brasil, Girlandia Alexandre; https://orcid.org/0000-0002-5455-7141; http://lattes.cnpq.br/1402295792093274; Padilha, Alessandra Simao; http://lattes.cnpq.br/7658998034219799
    The postmenopausal period is considered a milestone for the emergence of chronic noncommunicable diseases, including cardiovascular diseases. In this context hypertension and endothelial dysfunction form the basis of the main risk factors and injuries. The introduction of nutraceuticals as therapeutic alternatives has attracted the attention of researchers for presenting promising results. These include ellagic acid, a phytochemical with potent antioxidant properties found in fruits, plants, and nuts. Therefore, the objective of this research was to evaluate the effects of ellagic acid treatment on vascular reactivity of resistance arteries in an experimental model of hypertension and menopause. Therefore 40 SHR rats were evaluated for 4 weeks and separated into 5 groups according to treatment: vehicle-treated SHAM (carboxymethylcellulose); OVX, castrated and vehicle treated; OAE, castrated and treated with ellagic acid (10 mg / kg / day); OE2, castrated and treated with estrogen (1g / kg / day); OAE + E2, treated with ellagic acid and estrogen. Mesenteric artery rings were maintained in vitro and subjected to contraction strength tests in the absence and presence of the nitric oxide synthase enzyme inhibitor to record the effect of treatments and the participation of nitric oxide (NO). Vessel samples were taken for biochemical analysis. Castration produced an increase in blood pressure (MAP: 190.4 ± 4.4 mmHg); effect that did not occur in groups treated with ellagic acid (MAP: 165.7 ± 1.4 mmHg, p