Preditores de mortalidade e anos de vida perdidos ajustados por incapacidade (DALY) no traumatismo cranioencefálico grave em uma capital do sudeste do Brasil: um estudo observacional prospectivo

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dc.contributor.advisor1Arêas, Fernando Zanela da Silva
dc.contributor.advisor1IDhttps://orcid.org/0000-0002-2068-2606
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/2219697069216192
dc.contributor.authorGrobério, Rodrigo Miranda
dc.contributor.authorIDhttps://orcid.org/0009-0007-0005-7209
dc.contributor.authorLatteshttp://lattes.cnpq.br/7464873031004308
dc.contributor.referee1Salarolli, Luciane Bresciani
dc.contributor.referee1IDhttps://orcid.org/0000-0002-1881-0306
dc.contributor.referee1Latteshttp://lattes.cnpq.br/3503255904138561
dc.contributor.referee2Schwarzbold, Marcelo Liborio
dc.contributor.referee2IDhttps://orcid.org/0000-0002-7260-7704
dc.contributor.referee2Latteshttp://lattes.cnpq.br/0866862539864076
dc.contributor.referee3Gouvêa, Sônia Alves
dc.contributor.referee3IDhttps://orcid.org/0000-0001-5180-471X
dc.contributor.referee3Latteshttp://lattes.cnpq.br/7268228122543743
dc.date.accessioned2026-02-12T12:09:20Z
dc.date.available2026-02-12T12:09:20Z
dc.date.issued2025-08-21
dc.description.abstractSevere traumatic brain injury (TBI) is a highly complex clinical condition and one of the leading causes of premature death and long-term functional disability worldwide. In Brazil, the lack of region-specific studies with robust data limits the understanding of its actual magnitude, especially in understudied areas. This study aimed to identify the main predictors of mortality and estimate the burden of disease—expressed in disability-adjusted life years (DALY) —in patients with severe TBI treated at a referral hospital in the metropolitan area of Vitória, Espírito Santo. This was a prospective, observational cohort study including 737 adult patients diagnosed with severe TBI (Glasgow Coma Scale ≤ 8), conducted between May 2021 and May 2023. Clinical, sociodemographic, laboratory, and neurosurgical variables were analyzed using binary logistic regression. The burden of disease was calculated based on the sum of years of life lost due to premature death (YLL) and years lived with disability (YLD). The overall mortality rate was 52.1%, predominantly affecting young men (81.4%), with a mean age of 44.4 years. Falls from standing height were the most frequent cause of injury (32.8%). In the acute phase (up to 7 days), mortality was independently associated with decompressive craniectomy, use of vasoactive drugs, and the presence of associated trauma. In the subacute phase (8 to 112 days), intracranial pressure monitoring (ICP) and thrombocytopenia were significant predictors of death. In the chronic phase (after 113 days), age over 65 years was the main predictor. The total burden of disease was estimated at 22,322.23 DALYs over 24 months, with a mean of 30.28 DALYs per patient and 593.41 DALYs per 100,000 inhabitants/year. The findings highlight the substantial impact of severe TBI on regional public health, emphasizing the urgent need for targeted prevention, care, and rehabilitation strategies focused on high-risk populations.
dc.description.resumoresumo
dc.description.sponsorshipFundação de Amparo à Pesquisa e Inovação do Espírito Santo (FAPES)
dc.formatText
dc.identifier.urihttp://repositorio.ufes.br/handle/10/20875
dc.languagepor
dc.language.isopt
dc.publisherUniversidade Federal do Espírito Santo
dc.publisher.countryBR
dc.publisher.courseMestrado em Ciências Fisiológicas
dc.publisher.departmentCentro de Ciências da Saúde
dc.publisher.initialsUFES
dc.publisher.programPrograma de Pós-Graduação em Ciências Fisiológicas
dc.rightsopen access, restricted access ou embargoed access
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectPalavra-chave
dc.subject.cnpqFisiologia
dc.titlePreditores de mortalidade e anos de vida perdidos ajustados por incapacidade (DALY) no traumatismo cranioencefálico grave em uma capital do sudeste do Brasil: um estudo observacional prospectivo
dc.title.alternativeTítulo alternativo do documento e/ou traduzido em outro idioma
dc.typemasterThesis
foaf.mboxemail@ufes.br
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