Efeito do curto prazo da utilização de pressão positiva contínua ou de exercício aeróbico moderado sobre o estresse oxidativo e o perfil inflamatório na apneia obstrutiva do sono
Nenhuma Miniatura disponível
Data
2019-06-06
Autores
Borges, Ytalo Goncalves
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Federal do Espírito Santo
Resumo
abstract
Background: Previous studies have shown that the levels of oxidative stress, inflammatory and cell-free DNA markers are increased in individuals suffering from obstructive sleep apnea (OSA). The effects of medium to long-term CPAP therapy and physical activity in decreasing these levels have been somewhat explored. Here we propose to evaluate the effects of short-term CPAP therapy and moderateintensity aerobic exercise in moderate to severe OSA patients. Methods:39 Recruited patients, randomly divided into CPAP (n=18) (with and without humidifier) and exercise groups (n=21), were all submitted to the Epworth Sleepiness Scale and the Pittsburgh questionnaire. Blood samples weretaken and biomarkers for lipid and protein oxidation, as well as pro and anti-inflammatory cytokines and cell-free DNA were quantified, before and after 8 weeks of either CPAP therapy or moderateintensity aerobic exercise. Results: After 8 weeks of either CPAP therapy or exercise no significant differences were observed in the levels of cell-free DNA, oxidative stress and inflammation markers, except for an increase in AOPP and IL-17A levels in individuals who went through CPAP, which were higher when the CPAP device was used without the humidifier. We have also observed that the 8-week interventions were mostly unable to improve sleep quality and sleepiness indexes. Conclusions: Our main conclusion is that short-term treatment for OSA, be it CPAP therapy or moderate-intensityaerobic exercise, is not sufficient to significantly alter either the oxidative stress and inflammatory profiles or the cell-free DNA levels of moderate to severe OSA patients, affecting sleep quality parameters only in a modest way.
Background: Previous studies have shown that the levels of oxidative stress, inflammatory and cell-free DNA markers are increased in individuals suffering from obstructive sleep apnea (OSA). The effects of medium to long-term CPAP therapy and physical activity in decreasing these levels have been somewhat explored. Here we propose to evaluate the effects of short-term CPAP therapy and moderateintensity aerobic exercise in moderate to severe OSA patients. Methods:39 Recruited patients, randomly divided into CPAP (n=18) (with and without humidifier) and exercise groups (n=21), were all submitted to the Epworth Sleepiness Scale and the Pittsburgh questionnaire. Blood samples weretaken and biomarkers for lipid and protein oxidation, as well as pro and anti-inflammatory cytokines and cell-free DNA were quantified, before and after 8 weeks of either CPAP therapy or moderateintensity aerobic exercise. Results: After 8 weeks of either CPAP therapy or exercise no significant differences were observed in the levels of cell-free DNA, oxidative stress and inflammation markers, except for an increase in AOPP and IL-17A levels in individuals who went through CPAP, which were higher when the CPAP device was used without the humidifier. We have also observed that the 8-week interventions were mostly unable to improve sleep quality and sleepiness indexes. Conclusions: Our main conclusion is that short-term treatment for OSA, be it CPAP therapy or moderate-intensityaerobic exercise, is not sufficient to significantly alter either the oxidative stress and inflammatory profiles or the cell-free DNA levels of moderate to severe OSA patients, affecting sleep quality parameters only in a modest way.
Descrição
Palavras-chave
Aerobic exercise , Oxidative stress , Inflammation , OSA , CPAP , Exercício aeróbico , Estresse oxidativo , Exercício aeróbico , Inflamação , Inflamação