Alterações cardiovasculares induzidas pela peçonha da serpente Bothrops leucurus
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Data
2018-04-05
Autores
Naumann, Gustavo Baptista
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Universidade Federal do Espírito Santo
Resumo
Bothrops leucurus (white tail jararaca) is the main responsible for ophidian accidents in the northeastern region of Brazil and northern Espírito Santo. Several studies have evaluated the biochemical features of this snake’s venom, as well as its local effects. However, systemic effects – in particular cardiovascular effects – remain rather poorly explored. In the present study, we sought to investigate the acute cardiovascular activities induced by B. leucurus venom (VB) in vivo and in vitro. In anaesthetized rats it was demonstrated that BlV (10-100µg/kg) induces immediate and transient hypotension, while maximum response was observed in 5 min and a return to baseline was observed in ≈ 20 minutes. No change in the heart rate of the animals was observed. In vitro effects were evaluated on pre-contracted mesenteric artery rings with phenylephrine, employing a resistance myograph.
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Palavras-chave
Bothrops leucurus , vascular reactivity , phospholipase A2 , hypotension , reatividade vascular , hipotensão , fosfolipase A2
Citação
NAUMANN, Gustavo Baptista. Alterações cardiovasculares induzidas pela peçonha da serpente Bothrops leucurus. 2018. Tese (Doutorado em Ciências Fisiológicas) - Universidade Federal do Espírito Santo, Centro de Ciências da Saúde, Vitória, 2018.