Mestrado em Ciências Odontológicas

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Navegando Mestrado em Ciências Odontológicas por Autor "Bruneli, Giuliano Lozer"

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    Manejo e prognóstico de pacientes com cancer de cabeça e pescoço durante a pandemia de COVID-19
    (Universidade Federal do Espírito Santo, 2023-05-17) Bruneli, Giuliano Lozer; Zeidler, Sandra Lucia Ventorin Von; https://orcid.org/0000000288975747; http://lattes.cnpq.br/5785612863130498; https://orcid.org/0000-0003-2277-5854; http://lattes.cnpq.br/4073059624940944; Spano, Liliana Cruz; https://orcid.org/0000000262056988; http://lattes.cnpq.br/7451382455806895; Velloso, Tânia Regina Grão; https://orcid.org/0000-0001-6865-7955; http://lattes.cnpq.br/6427157237870625
    The COVID-19 pandemic has brought the need for the implementation of several precautions to prevent the spread of the new coronavirus, as well as measures for its control. Among the changes adopted are those in healthcare services, particularly in oncology services. To provide support for the necessary changes in the oncology service, we analyzed the clinical and pathological data of patients diagnosed with HNSCC treated at the Head and Neck Surgery Service of the Hospital Santa Rita de Cássia (HSRC) between October 2020 and October 2021, comparing the clinical outcome of patients infected and not infected by SARSCoV-2. The diagnosis of SARS-CoV-2 infection was performed using the realtime PCR (RT-PCR) technique before the surgical procedure. To compare the clinical outcomes of patients regarding the presence of the new coronavirus infection, prognostic factors for HNSCC patients such as investigation of preexisting comorbidities and tumor staging (TNM System, 8th Ed) were also considered in addition to analyzing the viral load of patients referred for chemotherapy. The Chi-Square test was used to analyze associated variables, while the Kaplan-Meier model was used to calculate survival curves. Of the 194 recruited patients, 99 cases confirmed diagnoses of head and neck cancer and underwent surgical treatment. The most frequent comorbidities were hypertension and diabetes mellitus. The oral cavity and larynx were the most affected anatomical sites, with 51% and 33%, respectively. A total of 61.6% of cases were classified as T3/T4 and 53.4% did not show lymph node involvement. The presence of comorbidities and lymph node metastasis was associated with reduced survival. Of the 99 patients, 8.1% (8/99) were infected with SARS-CoV2, but no difference was observed in overall survival according to SARS-CoV-2 infection (p=0.086), and viral load was not associated with vital status (p=0.456). We concluded that the presence of SARS-CoV-2 infection did not influence overall survival in patients with HNSCC.