Mestrado em Ciências Odontológicas

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    Análise da expressão de MMP-9 na mucosa jugal de pacientes com epidermólise bolhosa residentes no Espírito Santo
    (Universidade Federal do Espírito Santo, 2026-02-25) Corrêa, Raphaella Thayná Rodrigues; Souza, Letícia Nogueira da Gama de ; https://orcid.org/0000-0001-6330-996X; http://lattes.cnpq.br/2797885632539769; https://orcid.org/0009-0001-5434-5499; http://lattes.cnpq.br/7212892242281000; Pinheiro, João de Jesus Viana ; https://orcid.org/0000-0002-6914-6441; http://lattes.cnpq.br/1365260779826770; Barroso, Danielle Resende Camisasca ; https://orcid.org/0000-0003-1193-2113; http://lattes.cnpq.br/3989074593181674
    Epidermolysis Bullosa (EB) is a rare genetic disorder characterized by mucocutaneous fragility, blister formation, and functional impairments affecting multiple organ systems, including the oral cavity. Cellular and molecular studies of affected tissues may contribute to a better understanding of the diverse clinical phenotypes observed in EB. Matrix metalloproteinases (MMPs) are enzymes involved in tissue remodeling, embryonic development, and wound healing; however, their activity has also been associated with pathological conditions, including inflammation, carcinogenesis, and cell migration. Among the different MMPs, MMP-9 plays a role in both physiological and pathological processes, and its expression has been particularly described in the context of tumorigenesis, in both tumor and inflammatory cells. Within this context, the present study investigated MMP-9 expression in exfoliative cytology samples of the buccal mucosa from individuals with EB and explored potential clinicopathological correlations. Exfoliative cytology was selected due to its simplicity, reproducibility, atraumatic nature for fragile mucosae, and suitability for serial sampling. Immunocytochemistry with DAB chromogen was used for labeling. A total of 1,000 cells per patient were evaluated in a blinded manner by a single, previously calibrated investigator. The EB group comprised 20 patients, and the control group (n = 20) was matched for sex and age. Cells were classified as positive or negative for MMP-9 expression, and the Mann–Whitney test was applied for statistical analysis. Intragroup analysis revealed a significantly higher number of negative cells compared to positive cells in both the control and EB groups (p < 0.0001). When comparing groups, although an increase in MMP-9–positive cells was observed in the EB group, this finding was subtle and not statistically significant (p = 0.9948). No differences in staining patterns were observed when comparing severe EB subtypes (junctional EB and dystrophic EB) with their respective control group. Similarly, no sex-related differences in MMP-9 expression were identified (p = 0.2141). Qualitative analysis revealed the presence of an inflammatory infiltrate in 7 cases (35%) of the EB group, including 6 cases of dystrophic EB and 1 case of EB simplex; this finding was not observed in the control group. Overall, the results suggest a similar pattern of MMP-9 expression in buccal mucosa exfoliative cytology samples from EB and non-EB individuals. Conversely, inflammatory cells were detected exclusively in EB cases. Finally, exfoliative cytology proved to be a minimally invasive, cost-effective approach for oral mucosal surveillance, with potential value as an adjunctive tool for the longitudinal monitoring of patients with EB
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    Impacto da condição bucal na qualidade de vida de uma equipe de trabalhadores de serviços gerais – estudo transversal
    (Universidade Federal do Espírito Santo, 2026-02-10) Sampaio, Maiara Campos Linhares; Rosetti, Elizabeth Pimentel ; https://orcid.org/0000-0001-8539-3154; https://lattes.cnpq.br/2693147990422431; https://orcid.org/0009-0001-2461-9006; https://lattes.cnpq.br/7458499536603120; Barcellos, Ludmilla Awad ; https://orcid.org/0000-0003-3732-9515; https://lattes.cnpq.br/7262427405068645; Pacheco, Karina Tonini dos Santos ; https://orcid.org/0000-0002-4687-6062; https://lattes.cnpq.br/1634767264856221
    Health should be understood through the interaction of biological, psychological, and social factors, which directly influence quality of life. In this context, health and quality of life are configured as dynamic and interdependent concepts. This study aimed to evaluate the impact of oral health conditions on the quality of life of general services workers at the Health Sciences Center of the Federal University of Espírito Santo (CCS-UFES), as well as their association with socioeconomic status and the decayed, missing, and filled teeth index (DMFT). This is a descriptive-analytical study with a quantitative approach and a cross-sectional design. The randomized sample consisted of 122 individuals, calculated based on a 50% prevalence, a 95% confidence level, and a 5% margin of error. Data collection included the application of the Oral Health Impact Profile (OHIP-14) and the Brazilian Economic Classification Criterion (CCEB), in addition to clinical dental examinations to obtain the DMFT index. Statistical analyses were performed using IBM SPSS software, version 20, including descriptive analysis, Fisher’s exact test, independent samples t-test, Mantel–Haenszel method, and logistic regression, with a significance level set at 5% (p < 0.05). More than half of the participants (54.5%) reported an impact of oral health on their quality of life. The mean DMFT index was 9.14 (SD = 5.28). An association was observed between the presence of decayed teeth and four OHIP-14 dimensions, whereas tooth loss due to caries was associated with six of the seven evaluated dimensions. The greatest impacts were identified in the psychological discomfort and psychological disability domains. The impact on quality of life was more associated with individuals aged 40 years or younger, belonging to socioeconomic classes C, D, and E, and presenting decayed and/or missing teeth due to caries. The combined use of clinical (DMFT) and subjective (OHIP-14) indicators proved effective in providing a broader understanding of the repercussions of oral health conditions on quality of life, enabling the identification of more vulnerable groups and supporting the prioritization of oral health actions
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    Prevalência de traumatismo dentário em praticantes de esporte de contato das academias de luta de uma capital da região sudeste
    (Universidade Federal do Espírito Santo, 2026-02-05) Simonton, Gabriela Almeida Souza Leão; Miotto, Maria Helena Monteiro de Barros ; https://orcid.org/0000-0002-3227-7608; http://lattes.cnpq.br/4289442514763843; https://orcid.org/0000-0002-5405-3402; http://lattes.cnpq.br/1390805743308942; Barcellos, Ludmilla Awad ; https://orcid.org/0000-0003-3732-9515; http://lattes.cnpq.br/7262427405068645; Sanglard, Luciana Faria ; https://orcid.org/0000-0002-2520-7062; http://lattes.cnpq.br/4718823259148176
    INTRODUCTION: Dental injuries are considered a public health problem, as they cause functional, aesthetic, psychosocial and financial damage to the individual. They are the intersection point between dentistry and sports. OBJECTIVE: To verify the prevalence of dental trauma in wrestlers and its possible associations with sociodemographic and sport-related variables in acapital city in the southeastern region of Brazil. METHODOLOGY: This is an observational and cross-sectional study conducted with 284 athletes (coaches, professionals, semi-professionals, and amateurs) from 17 academies offering combat sports in Vitória-ES, Brazil. Data collection took place in October and November 2024 using a questionnaire containing sociodemographic information, access to oral health services, sport modality, occurrence of dental trauma during combat sports, use of mouthguards, and guidance on trauma. Descriptive and statistical analyses were performed using the chi-square test (p<0.05) and Odds Ratio to verify the strength of association between the variables. RESULTS: Most participants were male (n=203; 71.48%), single (n=142; 50%), under 25 years old (n=75; 26.41%), and practitioners of Jiu-Jitsu (n=79; 27.82%) and kickboxing (n=77; 27.11%). Of the athletes who suffered dental trauma during the fight (n=19; 6.69%), reported having experienced it once (n=9; 47.37%). The predominant type was enamel fracture (n=7; 36.84%), in the anterior teeth (n=9; 47.36%). Most were not using a mouthguard when they suffered the dental trauma (n=15; 78.95%), even though they considered its use important (n=229; 80.63%), and had not received guidance on the subject (n=237; 83.45%). A significant association was observed between age group and the occurrence of dental trauma. CONCLUSION: The highest prevalences of traumatic dental injuries were in Capoeira and Taekwondo, associated with the age group of 37 years or older. Furthermore, practitioners reported not using mouthguards and there was low levels of guidance on dental trauma
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    Barreiras e facilitadores à implementação de uma ferramenta digital de detecção precoce de câncer de boca na atenção primária à saúde : um estudo qualitativo das percepções dos profissionais de saúde
    (Universidade Federal do Espírito Santo, 2025-12-09) Menezes, Amanda Ferreira; Esposti, Carolina Dutra Degli ; https://orcid.org/0000-0001-8102-7771; http://lattes.cnpq.br/7465412734380334; Zeidler, Sandra Lúcia Ventorin von ; https://orcid.org/0000-0002-8897-5747; http://lattes.cnpq.br/5785612863130498; https://orcid.org/0000-0002-1002-2110; http://lattes.cnpq.br/2022867562359986; Silva, Everton Nunes ; https://orcid.org/0000-0001-8747-4185; http://lattes.cnpq.br/3121617627863531; Valle, Isabella Bittencourt do ; https://orcid.org/0000-0002-3221-3057; http://lattes.cnpq.br/3069021711512099
    Oral cancer (OC) is a public health problem in Brazil due to its high morbidity and mortality. The impact of OC can be reduced through diagnosis at early stages, when the chances of cure are greater and the patient's prognosis is favorable. Primary Health Care (PHC) is the main gateway to the Unified Health System (SUS) and is responsible for screening and early diagnosis of the disease. Digital technologies have been incorporated as support tools for screening high-risk populations for the disease. This study aimed to analyze the perception of PHC professionals regarding barriers and facilitators to the implementation of the web-responsive platform "SobreVidas", designed for screening and monitoring populations at risk for OC. This is an intervention research with a qualitative approach in which a semi-structured script based on the COM-B and TDF theoretical models was used to interview eight PHC professionals in Espírito Santo, Brazil. The results identified as barriers work overload, duplicate records, lack of interoperability with existing electronic health records, and technological infrastructure limitations. As facilitators, the clinical specificity of the tool for screening high-risk groups for OC, agility in clinical records, and the potential for improving clinical practice were highlighted. It is concluded that the adoption of digital technologies in PHC requires strategies that address organizational, structural, and behavioral factors to favor their effective incorporation into health services
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    Caracterização sociodemográfica, clínica e itinerária do carcinoma escamocelular oral em um centro de referência do estado do Espírito Santo
    (Universidade Federal do Espírito Santo, 2025-08-15) Guimarães, Mariana Barbosa ; Leitão, Águida Cristina Gomes Henriques; https://orcid.org/0000-0002-8591-3655 ; http://lattes.cnpq.br/2563401100488039; Barroso, Danielle Resende Camisasca; https://orcid.org/0000-0003-1193-2113 ; http://lattes.cnpq.br/3989074593181674; https://orcid.org/0009-0002-7378-980X ; http://lattes.cnpq.br/1829498964857800; Toporcov, Tatiana Natasha ; https://orcid.org/0000-0002-8929-5137 ; http://lattes.cnpq.br/5345064895953228; Esposti, Carolina Dutra Degli; https://orcid.org/0000-0001-8102-7771; http://lattes.cnpq.br/7465412734380334
    O carcinoma escamocelular (CEC) é tipo histopatológico mais comum do câncer de boca, ocupando o 8º lugar em incidência no Brasil. O sítio mais acometido é a borda lateral de língua, causado principalmente pelo alto consumo de tabaco e álcool, e o seu diagnóstico tardio é uma das principais causas de morbimortalidade elevada entre a população. Este estudo visa analisar o perfil dos pacientes portadores do CEC oral numa população do Espírito Santo (ES), de acordo com suas características sociodemográficas, clínicas e itinerária. Trata-se de um estudo transversal, coletado através de prontuários de pacientes submetidos a tratamento para o CEC oral no período de 2015 a 2023 em um centro de referência. Análise descritiva, Teste de Qui quadrado e Exato de Fisher foram utilizadas para análise das variáveis. Intervalos de tempos foram definidos para a investigação itinerária, bem como serviço ofertado e completude dos dados. Foram obtidos 48 casos, predominantemente homens (n=33, 68,7%), idade avançada (42 a 95 anos, média 60,7), pardos (n=33, 68,7%), tabagistas (n=19, 39,5%) e etilistas (n=21, 43,7%), com ensino fundamental incompleto (n=15, 31,2%). A maioria (n=29, 51,7%) das lesões estavam em língua, ulceradas e nodulares (n=26, 54,1%; n=10, 20,8%). A cirurgia foi o tratamento mais usado (n=35, 72,9%), e o serviço público o mais ofertado na consulta inicial (n=44, 91,6%) e tratamento (n=47, 100%). O intervalo da detecção da lesão pelo paciente até procurar atendimento em saúde obteve mediana de 6 (de 1 a 48) meses. O intervalo até o diagnóstico obteve mediana de 0,3 (de 0 a 65,7) meses, e o intervalo até o início do tratamento foi de 1 (de 0 a 15,8) mês. Houve associação entre pardos (p=0,04) e hipótese clínica de CEC (p=0,04) com o menor período de intervalo do paciente (0 6m), além da associação entre estágios iniciais I e II e tratamento cirúrgico (p=0,04). O perfil dos pacientes diagnosticados com CEC no ES evidenciam um padrão clássico e demonstram a relevância do serviço público. Os intervalos de tempo atendem a lei brasileira e seu estudo pode direcionar para políticas preventivas