Mioesteatose, prognóstico e toxicidade no câncer de mama: revisão sistemática e metanálise de estudos de coorte
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Data
2024-10-11
Autores
Silva, Naira Marceli Fraga
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Universidade Federal do Espírito Santo
Resumo
Myosteatosis is associated with a variety of negative outcomes in oncology, but in patients with breast cancer (BC) the results have been conflicting. Therefore, we sought to critically analyze the evidence on the association between myosteatosis, overall survival, progression/disease-free survival and adverse treatment events in BC. The review was conducted and reported according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Two independent reviewers screened, selected, and assessed the records. Sixteen studies were included. Myosteatosis affected between 13 and 61% of the patients evaluated and the protocols for its analysis were heterogeneous and generally reported incompletely. The analysis of current data did not support the hypothesis of a relationship between myosteatosis in women with BC and overall survival (HR: 1.04; 95%CI 0.98-1.11; p=0.23; I²=64%) or disease/progression-free survival (HR: 1.15; 95%CI 0.91-1.45; p=0.24; I²=73%). In addition, the results on adverse events were not uniform, which prevented them from being analyzed together. Finally, these results highlight the urgent need to establish minimum parameters for the analysis of myosteatosis, as well as the need to develop new studies to confirm the absence of these associations or the possible influence of assessment methods on the results obtained.
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Composição corporal , Qualidade muscular , Neoplasia maligna da mama