Mestrado em Nutrição e Saúde
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- ItemFatores associados ao risco para transtornos alimentares e alimentação emocional na população adulta com TDAH(Universidade Federal do Espírito Santo, 2025-04-29) Silva, Gabriela Grillo da; Soares, Fabíola Lacerda Pires; https://orcid.org/; http://lattes.cnpq.br/; https://orcid.org/; http://lattes.cnpq.br/; Rocha, Liane Murari; https://orcid.org/; http://lattes.cnpq.br/; Viana, Mirelle Lomar; https://orcid.org/; http://lattes.cnpq.br/; Lucas, Maria Salete Junqueira; https://orcid.org/; http://lattes.cnpq.br/; Cabrini, Danielle; m; mIntroduction: The characteristics of Attention Deficit Hyperactivity Disorder (ADHD) may contribute to the development of eating disorders (EDs) in this population, in addition to their frequent engagement in emotional eating. Objective: To assess the risk of EDs and emotional eating, as well as their associated factors, in the adult population with ADHD residing in the Metropolitan Region of Greater Vitória (RMGV). Method: The study included individuals aged 18 to 59 years with a medical diagnosis of ADHD. Data were collected through an online questionnaire using self-administered instruments, which included sociodemographic, clinical, lifestyle, nutritional status, and self-compassion score assessments. ED risk was evaluated using the Eating Disorders Examination Questionnaire (EDE-Q), while emotional eating was assessed using the "Emotional Eating" subscale of the Three-Factor Eating Questionnaire – reduced 21-item version (TFEQ-R21). Data analysis was performed using JASP software, version 18.3. Results: A total of 151 individuals participated in the study, 68.7% of whom were female. The median age was 25 years, and most participants did not live with a partner. The median and interquartile range of the EDE-Q score assessing ED risk was 2.32 (2.41). Regarding the emotional eating score, the value was 50.00 (44.44). Each 1-point increase in BMI was associated with a 0.053-point increase in ED risk (p = 0.005). Conversely, each 1-point increase in the self-compassion score was associated with a 0.339-point decrease in the EDE-Q score (p = 0.009). Engaging in dieting practices was also linked to an increased risk of EDs. Mediation analysis revealed that emotional eating mediates the relationship between these variables and ED risk. When analyzing the factors associated with emotional eating as an outcome, higher BMI, dieting practices, marital status, and the presence of comorbidities were found to be predictors of increased emotional eating in this population. Conclusion: Higher BMI and dieting practices are associated with increased ED risk, whereas self compassion appears to be a protective factor. Emotional eating mediates the relationship between these variables and ED risk. Additionally, higher BMI, dieting practices, marital status, and the presence of comorbidities are predictors of increased emotional eating in this population.
- ItemDetecção e quantificação de cafeína em suplementos de creatina por espectroscopia no infravermelho médio e algoritmos de inteligência artificial(Universidade Federal do Espírito Santo, 2025-12-03) Pires, Maria Clara da Cruz; Haraguchi, Fabiano Kenji; https://orcid.org/0000-0002-1019-8888; http://lattes.cnpq.br/7280084109670510; https://orcid.org/0009-0002-4791-4232; http://lattes.cnpq.br/8701262202956273; São José, Jackline Freitas Brilhante de; https://orcid.org/0000-0002-6592-5560; http://lattes.cnpq.br/9686717495086118; Salgueiro, Diego Forte de Souza; https://orcid.org/0000-0002-5712-1546; http://lattes.cnpq.br/2047793346776825Due to the economic relevance and widespread popularity of dietary supplements (DS), combined with weaknesses in regulatory oversight, these products have become susceptible to fraudulent practices, particularly adulteration, reinforcing the need for alternative methods to assess their quality and safety. This study aimed to develop machine learning algorithms for the detection and quantification of caffeine (CAF) in creatine (CRE) supplements using mid infrared spectroscopy associated with artificial intelligence (AI) models. Five commercial CRE brands were adulterated with CAF at concentrations ranging from 2 to 20%, generating samples which, together with the corresponding pure formulations, resulted in a total of 56 samples. The mixtures were analyzed in triplicate using a Bruker® ALPHA II FTIR spectrometer (4 cm⁻¹ resolution, 32 scans, 4,000–400 cm⁻¹), yielding 168 spectra, which were processed using Orange Data Mining® (v.3.38.1). The dataset was divided into calibration (CAL, 70%) and prediction (PRED, 30%) sets and assigned to class 0 (n = 18) for pure samples and class 1 (n = 150) for adulterated samples. The following multivariate analyses were applied: Principal Component Analysis (PCA), Support Vector Machine (SVM), and Partial Least Squares (PLS). Two additional blind prediction tests were conducted: one using three known CRE brands (18 adulteration levels, 0–20%) and another using one CRE brand unknown to the models (six adulteration levels), both prepared independently by different researchers. PCA of pure CRE and CAF samples showed an explained variance (EV) of 98.5% (PC1 = 97.4%; PC2 = 1.1%), whereas PCA of the complete dataset showed an EV of 86.75% (PC1 = 68.61%; PC2 = 18.14%). In the test, the SVM achieved sensitivity (SEN) of 100% and specificity (SPEC) of 75%. The PLS yielded a coefficient of determination (R²) of 0.75 and a root mean square error of prediction (RMSEp) of 3.06%. The limits of detection (LoD) and quantification (LoQ) were 0.55% and 1.82%, respectively. In the first blind test, the SVM reached 100% SEN starting at 1.71% adulteration; the PLS achieved an R² of 0.67 and an RMSE of 2.84%. In the second blind test, SEN was 80%, and the PLS achieved an R² of 0.73 and an RMSE of 2.11%. Overall, the results demonstrate that the AI-based algorithms were effective for the detection and quantification of CAF in CRE supplements, representing a practical and scalable tool for assessing product quality and authenticity
- ItemImpacto da força muscular na mortalidade em indivíduos em hemodiálise(Universidade Federal do Espírito Santo, 2025-12-05) Klippel, Leticia de Paiva Souza; Salaroli, Luciane Bresciani ; https://orcid.org/0000-0002-1881-0306 ; http://lattes.cnpq.br/3503255904138561; https://orcid.org/0009-0006-8811-2913 ; http://lattes.cnpq.br/9775823468302659; Lopes, Andressa Bolsoni; https://orcid.org/0000-0003-1244-5667 ; http://lattes.cnpq.br/0097480808041638; Moraes, Cristiane; https://orcid.org/0000-0001-8573-0798 ; http://lattes.cnpq.br/0775508637215738; Daboin, Blanca Elena Guerrero; https://orcid.org/0000-0001-9052-1923 ; http://lattes.cnpq.br/0523231791561678; Gomes, Daiene Rosa; https://orcid.org/0000-0002-1831-1259; http://lattes.cnpq.br/3886271497910568Introduction: Chronic kidney disease (CKD) is directly associated with an increase in mortality, with a rise of over 40% in recent decades. It is well-established that individuals undergoing hemodialysis typically experience diminished muscle strength, and this impairment is linked to adverse outcomes, a worse prognosis, and an elevated risk of mortality. Given that mortality rates are particularly high during the first year of hemodialysis, handgrip strength (HGS) may serve as an important indicator for early diagnosis and potentially offer a more accurate prognosis. Objective: To assess the relationship between reduced muscle strength and mortality in individuals undergoing hemodialysis in the Região Metropolitana da Grande Vitória (RMGV). Methods: This is a retrospective cohort study. The sociodemographic and clinical variables were taken from a study of individuals on hemodialysis conducted in 2019. Mortality data was obtained from death certificates from 2019 to 2022, recorded in the Mortality Information System (SIM). HGS was classified according to the cutoff point of <16kg for women and <27kg for men and into tertiles in the subsequent study. Survival curves were drawn using the Kaplan Meier method. Models were built using Cox regression. Analyses were carried out using R Software (4.4.1), with a significance level of p<0.05. Preliminary results: 994 individuals were included and of these, 363 died. Reduced HGS increased the risk of mortality by 49%, even after adjustment (p<0.001). When evaluated in tertiles, FPM proved to be a better predictor of mortality, with a 1.81-fold increase in the risk of death (p<0.001). Muscle mass indicators — Adductor Pollicis Muscle Thickness (APMT) and Arm Muscle Area (AMA), did not show a significant association with mortality.
- ItemDietas low carb e low fat e parâmetros cardiometabólicos em participantes do estudo longitudinal de saúde do adulto – ELSA-Brasil(Universidade Federal do Espírito Santo, 2025-06-24) Azevedo, Leticia Batista de; Martinez, Oscar Geovanny Enriquez; https://orcid.org/0000-0003-4561-122X; http://lattes.cnpq.br/0493747317645178; Molina, Maria del Carmen Bisi; https://orcid.org/0000-0002-8614-988X; http://lattes.cnpq.br/9238370951122705; https://orcid.org/0000-0002-7810-0621; http://lattes.cnpq.br/7792347811592236; Guandalini, Valdete Regina; https://orcid.org/0000-0003-2266-6113; http://lattes.cnpq.br/7931552401781397; Pereira, Taísa Sabrina Silva; https://orcid.org/0000-0002-5922-7424; http://lattes.cnpq.br/6842932234822212Introduction: Chronic noncommunicable diseases are responsible for approximately 74% of global deaths and are strongly associated with unhealthy dietary patterns. Dietary strategies such as low-carb (LCD) and low-fat (LFD) diets have been studied for their potential benefits on cardiometabolic health. Objective: To evaluate the association between adherence to LCD and LFD diets and cardiometabolic outcomes in participants of the Longitudinal Study of Adult Health (ELSA-Brasil), with three specific objectives: (1) to identify sociodemographic, health, and lifestyle factors associated with adherence to LCD and LFD; (2) to analyze the longitudinal association between LCD and cardiometabolic parameters in individuals with and without diabetes; and (3) to investigate the association between adherence to a LFD and variations in waist circumference (WC) in participants of the ELSA-Brasil cohort. Methods: Cross sectional (2008–2010) and longitudinal (2008–2010 and 2017–2019) analyses, whose baseline comprised 15,105 adults aged 35 to 74 years. Information was obtained through interviews, clinical, laboratory, and standardized anthropometric examinations. Dietary intake was assessed by the Food Frequency Questionnaire, with classification of DLC (<45% carbohydrates) and DLF (<30% total fat and <10% salty foods). Logistic and quantile regression models were used, adjusted for sociodemographic and behavioral variations, extensions in the SATA Software version 16.0, statistical significance at p<0.05. Results: Adherence to DLC was higher among individuals with overweight (OR = 1.35), larger waist circumference (OR = 1.45 in men), and former smokers (OR = 1.32 in women). Adherence to DLF was lower among non white individuals (OR = 0.71 in women), ≥52 years (OR = 0.59), and with low physical activity (OR = 0.57 in men). Adherence to DLC over a mean of 9 years among individuals without diabetes was associated with reduced insulin (β = –0.33 µIU/mL), HOMA-IR (β = –0.11), and HOMA-B (β = –4.95), despite the level of increase in BMI. Among individuals with diabetes, greater reductions in HOMA-IR (β = –1.25) and insulin (β = –3.61) were observed. Finally, sustained adherence to DLF (14.4% of the sample) was associated with protection against WC gain, particularly in individuals with a greater tendency to accumulate abdominal adiposity. Conclusion: Adherence to DLC and DLF was associated with improved cardiometabolic indicators, especially insulin sensitivity and cardiovascular risk. The effects were observed even with moderate adherence and varied according to sociodemographic and lifestyle characteristics.
- ItemDistribuição de fluidos corporais na dinâmica do ângulo de fase durante diferentes fases da perda de peso induzida pelo bypass gástrico(Universidade Federal do Espírito Santo, 2025-07-03) Brito, Beatriz Bobbio de; Lopes, Andressa Bolsoni; https://orcid.org/0000-0003-1244-5667; http://lattes.cnpq.br/0097480808041638; Haraguchi, Fabiano Kenji; https://orcid.org/0000-0002-1019-8888; http://lattes.cnpq.br/7280084109670510; https://orcid.org/0000-0002-6616-4994; http://lattes.cnpq.br/9622656389526243; Lopes Júnior, Luís Carlos; https://orcid.org/0000-0002-2424-6510; http://lattes.cnpq.br/5919501773501977; Amaral, Joana Ferreira do; https://orcid.org/0000-0001-8415-6333; http://lattes.cnpq.br/2800287239112001Introduction: The phase angle (PhA) is underexplored in severe obesity and after bariatric surgery, despite being a relevant indicator that reflects bodily and cellular changes during weight loss. Objective: This study aimed to evaluate the dynamics of the phase angle (PhA) and identify the factors associated with body composition over a 12-month period following Roux-en-Y gastric bypass (RYGB) surgery. Material and Methods: Analytical observational retrospective cohort study with male and female patients who underwent RYGB, with body composition assessed at four time points: before surgery and at 2, 6, and 12 months postoperatively. Data were analyzed using the Friedman test with a significance level of 5%. Spearman correlation and multiple linear regression were also performed. Results: From a large screened cohort, 60 patients completed the full longitudinal analysis. PhA values decreased after RYGB and stabilized over time. Weight, BMI, waist circumference, fat mass, fat-free mass, and total body water significantly decreased at each assessment point (p<0.05). PhA values were associated with the extracellular-to-intracellular water ratio (ECW:ICW ratio) at the postoperative time points (p<0.05). Conclusion: PhA values tend to decrease initially after RYGB, followed by later stabilization, with the ECW:ICW ratio being the main determinant in the postoperative period. However, given the complexity of severe obesity, other factors may also influence PhA in the preoperative period, highlighting the need for a multifactorial interpretation and future analytical studies.