Mestrado em Nutrição e Saúde
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- ItemAtuação dos capsinóides sobre o perfil inflamatório e morfofisiológico do tecido hepático de ratos com obesidade induzidos por dieta hiperlipídica(Universidade Federal do Espírito Santo, 2025-09-23) Simmer, Luisa Martins; Leopoldo, André Soares ; https://orcid.org/0000-0001-5999-2671; http://lattes.cnpq.br/5912424547697713; Leopoldo, Ana Paula Lima; https://orcid.org/0000-0002-4049-4418; http://lattes.cnpq.br/8738001726549455; https://orcid.org/0000-0002-0241-4253; http://lattes.cnpq.br/1504358574701495; Lopes, Andressa Bolsoni; https://orcid.org/0000-0003-1244-5667; http://lattes.cnpq.br/0097480808041638; Campos, Dijon Henrique Salomé de; https://orcid.org/0000-0002-4933-0604; http://lattes.cnpq.br/4940228608089976Introduction: Among the morbidities triggered by obesity that can cause systemic damage, there is fatty liver disease associated with metabolic dysfunction (FHD), whose progression stems from the composition of lipid molecules in the liver. The growing search for natural and functional foods as an alternative to improve health highlights peppers, due to their wide use. Capsinoids, bioactive compounds present in peppers of the genus Capsicum annuum, have been trained to promote weight loss and increased caloric expenditure.Objective: To investigate the influence of capsnoid treatment on the prevention of liver disease based on inflammatory and hepatic parameters in obese rats. Methods: Wistar rats were induced, maintained, and redistributed after developing obesity induced by a high-fat diet, subjected to either the absence or presence of capsinoids treatment for 8 weeks. At the end of the 27-week experimental protocol, the animals were euthanized, and blood, plasma, adipose tissue, and liver tissue were collected for morphometric analyses. This study was approved by CEUA-UFES nº08/22. Data analysis was performed using the Kolmogorov-Smirnov normality test, and results are expressed as mean ± standard deviation. Comparisons between groups were performed using Student's t-test, and comparisons of body mass evolution and the glucose tolerance test (GTT) were performed using a two-way ANOVA in a repeated measures model, complemented by Bonferroni's multiple comparisons test. Data analysis and graphs were performed using the Graphpad Prism 8 statistical program, and the significance level was 5%. Results: The obese group (Ob), compared to the control group (C), showed higher values for body mass, caloric intake, glycemic levels, area under the glucose curve, and higher hormonal dosages of insulin, leptin, and cholesterol. However, a lower value for food intake was observed. In the capsinoid treated group (ObCap), when compared to the Ob group, no statistical differences were observed in the parameters of body mass, food intake, caloric intake, feed efficiency, adiposity index, morphometric analysis of adipose tissue, glycemic profile, and inflammatory profile. However, there was a reduction in plasma levels of ghrelin and cholesterol. Regarding the diagnosis and degree of progression of GAD, the ObCap animals showed a decrease in the amount of hepatic fat (ObCap
- ItemEfeito dos capsinóides e do exercício físico na modulação do perfil inflamatório e tecido hepático na condição de obesidade(Universidade Federal do Espírito Santo, 2025-12-16) Nunes, Fabiane Merigueti; Leopoldo, André Soares; https://orcid.org/0000-0001-5999-2671; http://lattes.cnpq.br/5912424547697713; Leopoldo, Ana Paula Lima; https://orcid.org/0000-0002-4049-4418; http://lattes.cnpq.br/8738001726549455; https://orcid.org/0009-0003-2045-3584; http://lattes.cnpq.br/6786521209492281; Bocalini, Danilo Sales; https://orcid.org/0000-0003-3993-8277; http://lattes.cnpq.br/6290090639004596; Evangelista, Fabiana de Sant’Anna; https://orcid.org/0000-0002-8103-6923; http://lattes.cnpq.br/8871159227482154Introduction: Obesity is associated with a chronic low-grade inflammatory state, which results in metabolic changes and promotes the development of Metabolic Steatotic Liver Disease (MSLD). Physical exercise and natural compounds, such as capsinoids, stand out for presenting benefits in energy expenditure, aiding in the loss of body mass and adiposity, in addition, they suggest influencing the deposition of hepatic fat. Therefore, the objective of this study is to analyze the effects of capsinoid supplementation, combined or not with physical exercise, on the inflammatory profile and liver tissue of rats with obesity induced by a high-fat diet. Methods: Wistar rats were randomly separated into two distinct groups according to the diet offered (DP/C = standard/control diet or DH/Ob = high-fat/obese diet) to characterize obesity for 19 weeks. After this period, the Ob group was randomized regarding the absence or presence of treatment with capsinoids (10 mg/kg/day) and/or aerobic physical exercise for 8 weeks, being divided into Obese (Ob), Obese Capsinoids (ObCap), Obese Trained (ObTr) and Obese Capsinoids Trained (ObCapTr). Body composition and metabolic comorbidities were assessed using glycemic, hormonal, and inflammatory parameters. Liver disease characterization and progression were evaluated. This study was approved by CEUA-UFES nº08/22. Data normality was assessed using the Kolmogorov–Smirnov test. Results were expressed as mean ± standard deviation, and comparisons were performed using Student's t-test or two-way ANOVA with repeated measures, followed by Tukey or Bonferroni post-hoc tests, adopting 5%. Results: Final body mass, fat deposits, and total body fat were higher in the Ob group (Ob>C), confirming the obesity induction protocol. In the obese groups undergoing treatment, no effects on body composition were observed. Insulin, leptin, IL-10, and adiponectin levels remained similar across groups. In contrast, ghrelin was reduced in all treated groups (ObCap, ObTr and ObCapTr). VO2max increased significantly in the ObCapTr group. The interventions were able to attenuate hepatic fat deposition in all treatment groups (ObCap, ObTr and ObCapTr). Conclusion: Although the interventions evaluated did not promote significant changes in body composition or inflammatory parameters in obese individuals, with the exception of a reduction in ghrelin levels, the combination of capsinoid treatment and physical exercise was effective in improving aerobic capacity, as evidenced by an increase in VO₂max. Significantly, all therapeutic approaches were able to attenuate hepatic fat accumulation, preventing the progression of MSLD, although with no additional effect from the combination of treatments. These findings reinforce the interventions as promising strategies for managing MSLD caused by obesity.
- ItemFatores associados ao risco para transtornos alimentares e alimentação emocional na população adulta com TDAH(Universidade Federal do Espírito Santo, 2025-04-29) Silva, Gabriela Grillo da; Soares, Fabíola Lacerda Pires; https://orcid.org/; http://lattes.cnpq.br/; https://orcid.org/; http://lattes.cnpq.br/; Rocha, Liane Murari; https://orcid.org/; http://lattes.cnpq.br/; Viana, Mirelle Lomar; https://orcid.org/; http://lattes.cnpq.br/; Lucas, Maria Salete Junqueira; https://orcid.org/; http://lattes.cnpq.br/; Cabrini, Danielle; m; mIntroduction: The characteristics of Attention Deficit Hyperactivity Disorder (ADHD) may contribute to the development of eating disorders (EDs) in this population, in addition to their frequent engagement in emotional eating. Objective: To assess the risk of EDs and emotional eating, as well as their associated factors, in the adult population with ADHD residing in the Metropolitan Region of Greater Vitória (RMGV). Method: The study included individuals aged 18 to 59 years with a medical diagnosis of ADHD. Data were collected through an online questionnaire using self-administered instruments, which included sociodemographic, clinical, lifestyle, nutritional status, and self-compassion score assessments. ED risk was evaluated using the Eating Disorders Examination Questionnaire (EDE-Q), while emotional eating was assessed using the "Emotional Eating" subscale of the Three-Factor Eating Questionnaire – reduced 21-item version (TFEQ-R21). Data analysis was performed using JASP software, version 18.3. Results: A total of 151 individuals participated in the study, 68.7% of whom were female. The median age was 25 years, and most participants did not live with a partner. The median and interquartile range of the EDE-Q score assessing ED risk was 2.32 (2.41). Regarding the emotional eating score, the value was 50.00 (44.44). Each 1-point increase in BMI was associated with a 0.053-point increase in ED risk (p = 0.005). Conversely, each 1-point increase in the self-compassion score was associated with a 0.339-point decrease in the EDE-Q score (p = 0.009). Engaging in dieting practices was also linked to an increased risk of EDs. Mediation analysis revealed that emotional eating mediates the relationship between these variables and ED risk. When analyzing the factors associated with emotional eating as an outcome, higher BMI, dieting practices, marital status, and the presence of comorbidities were found to be predictors of increased emotional eating in this population. Conclusion: Higher BMI and dieting practices are associated with increased ED risk, whereas self compassion appears to be a protective factor. Emotional eating mediates the relationship between these variables and ED risk. Additionally, higher BMI, dieting practices, marital status, and the presence of comorbidities are predictors of increased emotional eating in this population.
- ItemDetecção e quantificação de cafeína em suplementos de creatina por espectroscopia no infravermelho médio e algoritmos de inteligência artificial(Universidade Federal do Espírito Santo, 2025-12-03) Pires, Maria Clara da Cruz; Haraguchi, Fabiano Kenji; https://orcid.org/0000-0002-1019-8888; http://lattes.cnpq.br/7280084109670510; https://orcid.org/0009-0002-4791-4232; http://lattes.cnpq.br/8701262202956273; São José, Jackline Freitas Brilhante de; https://orcid.org/0000-0002-6592-5560; http://lattes.cnpq.br/9686717495086118; Salgueiro, Diego Forte de Souza; https://orcid.org/0000-0002-5712-1546; http://lattes.cnpq.br/2047793346776825Due to the economic relevance and widespread popularity of dietary supplements (DS), combined with weaknesses in regulatory oversight, these products have become susceptible to fraudulent practices, particularly adulteration, reinforcing the need for alternative methods to assess their quality and safety. This study aimed to develop machine learning algorithms for the detection and quantification of caffeine (CAF) in creatine (CRE) supplements using mid infrared spectroscopy associated with artificial intelligence (AI) models. Five commercial CRE brands were adulterated with CAF at concentrations ranging from 2 to 20%, generating samples which, together with the corresponding pure formulations, resulted in a total of 56 samples. The mixtures were analyzed in triplicate using a Bruker® ALPHA II FTIR spectrometer (4 cm⁻¹ resolution, 32 scans, 4,000–400 cm⁻¹), yielding 168 spectra, which were processed using Orange Data Mining® (v.3.38.1). The dataset was divided into calibration (CAL, 70%) and prediction (PRED, 30%) sets and assigned to class 0 (n = 18) for pure samples and class 1 (n = 150) for adulterated samples. The following multivariate analyses were applied: Principal Component Analysis (PCA), Support Vector Machine (SVM), and Partial Least Squares (PLS). Two additional blind prediction tests were conducted: one using three known CRE brands (18 adulteration levels, 0–20%) and another using one CRE brand unknown to the models (six adulteration levels), both prepared independently by different researchers. PCA of pure CRE and CAF samples showed an explained variance (EV) of 98.5% (PC1 = 97.4%; PC2 = 1.1%), whereas PCA of the complete dataset showed an EV of 86.75% (PC1 = 68.61%; PC2 = 18.14%). In the test, the SVM achieved sensitivity (SEN) of 100% and specificity (SPEC) of 75%. The PLS yielded a coefficient of determination (R²) of 0.75 and a root mean square error of prediction (RMSEp) of 3.06%. The limits of detection (LoD) and quantification (LoQ) were 0.55% and 1.82%, respectively. In the first blind test, the SVM reached 100% SEN starting at 1.71% adulteration; the PLS achieved an R² of 0.67 and an RMSE of 2.84%. In the second blind test, SEN was 80%, and the PLS achieved an R² of 0.73 and an RMSE of 2.11%. Overall, the results demonstrate that the AI-based algorithms were effective for the detection and quantification of CAF in CRE supplements, representing a practical and scalable tool for assessing product quality and authenticity
- ItemImpacto da força muscular na mortalidade em indivíduos em hemodiálise(Universidade Federal do Espírito Santo, 2025-12-05) Klippel, Leticia de Paiva Souza; Salaroli, Luciane Bresciani ; https://orcid.org/0000-0002-1881-0306 ; http://lattes.cnpq.br/3503255904138561; https://orcid.org/0009-0006-8811-2913 ; http://lattes.cnpq.br/9775823468302659; Lopes, Andressa Bolsoni; https://orcid.org/0000-0003-1244-5667 ; http://lattes.cnpq.br/0097480808041638; Moraes, Cristiane; https://orcid.org/0000-0001-8573-0798 ; http://lattes.cnpq.br/0775508637215738; Daboin, Blanca Elena Guerrero; https://orcid.org/0000-0001-9052-1923 ; http://lattes.cnpq.br/0523231791561678; Gomes, Daiene Rosa; https://orcid.org/0000-0002-1831-1259; http://lattes.cnpq.br/3886271497910568Introduction: Chronic kidney disease (CKD) is directly associated with an increase in mortality, with a rise of over 40% in recent decades. It is well-established that individuals undergoing hemodialysis typically experience diminished muscle strength, and this impairment is linked to adverse outcomes, a worse prognosis, and an elevated risk of mortality. Given that mortality rates are particularly high during the first year of hemodialysis, handgrip strength (HGS) may serve as an important indicator for early diagnosis and potentially offer a more accurate prognosis. Objective: To assess the relationship between reduced muscle strength and mortality in individuals undergoing hemodialysis in the Região Metropolitana da Grande Vitória (RMGV). Methods: This is a retrospective cohort study. The sociodemographic and clinical variables were taken from a study of individuals on hemodialysis conducted in 2019. Mortality data was obtained from death certificates from 2019 to 2022, recorded in the Mortality Information System (SIM). HGS was classified according to the cutoff point of <16kg for women and <27kg for men and into tertiles in the subsequent study. Survival curves were drawn using the Kaplan Meier method. Models were built using Cox regression. Analyses were carried out using R Software (4.4.1), with a significance level of p<0.05. Preliminary results: 994 individuals were included and of these, 363 died. Reduced HGS increased the risk of mortality by 49%, even after adjustment (p<0.001). When evaluated in tertiles, FPM proved to be a better predictor of mortality, with a 1.81-fold increase in the risk of death (p<0.001). Muscle mass indicators — Adductor Pollicis Muscle Thickness (APMT) and Arm Muscle Area (AMA), did not show a significant association with mortality.