Obtenção de derivados triazólicosdo [6]-gingerol eavaliação dosseus potenciaiscitotóxicoscontra células tumorais HCT 116 e MCF-7
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Data
2020-02-13
Autores
Silva, William Cezar de Lima
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Universidade Federal do Espírito Santo
Resumo
Nowadays, cancer is still one of the great challenges for public health. The inefficiency of treatments available in conventional therapy and the adverse effects on the human body during treatments makes the disease one of the most lethal in the world, with significant mortality rates worldwide. Against this background, natural product chemistry occupies a prominent role in the search for new treatment alternatives by contributing to a spectrum of chemical structures that may be potentially promising in the discovery of new bioactive compounds. The compound [6] -gingerol is the main active substance in ginger (Zingiber officinale) and several studies have signaled its beneficial actions including antitumor. In this study, the isolation of this material and derivatizations based on the chemistry Click were obtained, obtaining 8 compounds. All chemical structures were determined by means of IR, NMR and HRMS data and evaluated against HCT 116 (colon carcinoma) and MCF-7 (breast carcinoma) cell lines at concentrations 5 μmol L-1 and 50 μmol L-1. At the first concentration none of the compounds had significant suppressive effects, however at 50 μmol L-1 suppressive effects were observed greater than 70% for compounds 2e, 2h (against HCT 116) and 2b, 2d, 2e, 2g and 2h (against MCF -7). These data show that the research is on the right track for potentially useful new compounds and suggest that new chemical modifications need to be thought in order to further potentiate the compounds by envisaging inhibition percentages at even lower concentrations
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[6]-Gingerol , Atividade citotóxica , Zingiber officinale , Semissíntese , Derivados triazólicos , Células tumorais , Cytotoxic activity , Semisynthesis , Triazole derivatives , Tumor cells