A relação entre o ângulo de fase e a melhora do estado anti-inflamatório de indivíduos submetidos à gastroplastia redutora em Y de Roux
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Data
2024-08-28
Autores
Gomes, Amanda Cristina Araujo
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Universidade Federal do Espírito Santo
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Introduction: Obesity leads to a state of chronic inflammation, characterized by an increase in inflammatory cytokines and infiltration of immune cells in adipose tissue, which can contribute to cellular dysfunction. Phase Angle (PA) is a non-invasive measurement derived from electrical bioimpedance, which has been associated with cellular integrity and metabolic health, and may therefore reflect inflammatory changes in response to weight loss induced by bariatric surgery. Objective: To evaluate the relationship between phase angle and parameters indicative of inflammatory status in patients undergoing bariatric surgery. Methodology: Prospective, observational study carried out with 23 volunteer patients from the Bariatric and Metabolic Surgery Program at a University Hospital. Participants were assessed at three points in time: preoperatively, approximately one month before surgery (T0) and postoperatively, approximately the 2nd (T1) and 6th (T2) months after surgery. Body weight, BMI, waist circumference (WC), fat mass (FF), fat-free mass (FFM), % weight loss, PA, serum concentrations of C-Reactive Protein (CRP), acid alpha-1-glycoprotein (AGP), adiponectin, Tumor Necrosis Factor Alpha (TNF-α) and resistin were analyzed. The data was statistically analyzed using the Statistical Package for the Social Sciences - SPSS, version 21.0. The Shapiro-Wilk test was applied to test the normality of the data, analysis of variance for repeated measures (ANOVA or Friedman test) and Spearman or Pearson correlations between PA and biochemical parameters and body parameters. A significance level of p<0.05 was adopted. Results: There was a significant reduction in body weight, BMI, MG, GLM, WC and PA over the time points, with different values for body weight, BMI, WC and MG between the time points (p<0.001). The percentage of weight loss was higher at T2 (p<0.001). All the biochemical parameters evaluated decreased significantly over the time points, with serum concentrations of AGP, CRP and resistin decreasing at T1 (p<0.05), while serum concentration of TNF-α decreased only at T2 (p<0.05). Serum adiponectin concentration increased from T1 onwards (p<0.001).A negative correlation was observed between variations in serum adiponectin concentrations and variations in PA values throughout the study (r=-0.480, p=0.027) and a negative correlation between serum adiponectin concentration and BMI (r=-0.264, p=0.038) and MG (r=-0.277, p=0.029) values, regardless of time. A positive correlation between serum TNF-α concentrations and BMI (r=0.338, p=0.004) and MG (r=0.335, p=0.004) values was also observed, as was the presence of a positive correlation between serum resistin concentration and MG values (r=0.245, p=0.042). Conclusion: The data suggest that smaller reductions in PA may be associated with an improved anti-inflammatory state during weight loss after BS.
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