Associação entre componentes da sarcopenia, gordura visceral e qualidade de vida relacionada à saúde: evidências de um estudo transversal em mulheres com câncer de mama
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Data
2023-08-18
Autores
Vieira, Mariana de Souza
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Universidade Federal do Espírito Santo
Resumo
Women with breast cancer have impairments in their health-related quality of life (HRQoL) associated with sarcopenia and visceral fat (GV). Therefore, this study has two objectives: 1. To investigate the association of sarcopenia components with HRQoL and its domains; and 2. Evaluate the association between QVRS and its domains with GV. Cross-sectional study, carried out in an outpatient clinic of a public hospital in southeastern Brazil, from January 2021 to December 2022. Women aged between 30 and 80 years, diagnosed with breast cancer, with ≤12 months of diagnosis, without metastasis or other malignancy and no recurrence. HRQoL domains were evaluated by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) and Breast Cancer-specific Core 23 (EORTC QLQ-BR23). The components of sarcopenia (muscle strength and mass and physical performance) were assessed by handgrip strength (HGS), appendicular skeletal muscle mass index (IMMEA) and Timed Up and Go test (TUGT), respectively. GV was performed by dual-energy X-ray absorptiometry (DXA). Linear regression models were maintained. The significance level adopted was p<0.05. 114 women with a mean age of 55.2 ± 11.3 years. FPM, IMMEA and TUGT were adequate in 87.7%; 79.8%; 95.6%, respectively. GV and body fat percentage were elevated by 62.5% and 86.0%, respectively. In linear regression, HGS lowered associated with cognitive function (p=0.047) and loss of appetite (p=0.012) and TUGT lowered with overall health (p=0.005) and functional scale (p=0.002) of the QLQ-C30. HGS and TUGT are associated with escalation of symptoms (p=0.017 and p=0.008, respectively) of the QLQ-BR23. The lowered GV associated with the functional scale (p=0.013), physical function (p=0.011), functional role (p=0.009), social function (p=0.047), symptom scale (p=0.003), fatigue (p= 0.043), pain (p<0.001) and insomnia (p=0.008). Muscle strength was associated with cognitive function and loss of appetite and physical performance with global health and functional scale, while high GV worsened functionality and fatigue, pain and insomnia in women with breast cancer.
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Qualidade de vida relacionada à saúde , Sarcopenia , Gordura visceral , Composição corporal , Sintomas