Mestrado em Ciências Odontológicas
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Navegando Mestrado em Ciências Odontológicas por Autor "Barros, Liliana Aparecida Pimenta de"
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- ItemAcurácia da autofluorescência para diagnóstico precoce de desordens orais potencialmente malignas: revisão sistemática(Universidade Federal do Espírito Santo, 2023-07-14) Freitas, Lara Weinert de; Barros, Liliana Aparecida Pimenta de; http://lattes.cnpq.br/8635277660080840; https://orcid.org/0000-0001-5999-0713; http://lattes.cnpq.br/9739624818971642; Lima, Thiago Farias Rocha; http://lattes.cnpq.br/3369191934450137; Lourenco, Simone de Queiroz ChavesStudies involving new tests and diagnostic methods used to screen for lesions that precede oral cancer are carried out, however, it becomes necessary to investigate the diagnostic accuracy index for its application. The objective of this Systematic Review (RS) was to collect the accuracy of autofluorescence in the early diagnosis of oral disorders with malignant potential (ODMPs). The search was carried out in nine electronic databases, three of which were gray literature, with no language or time restrictions. The studies included patients with ODMPs with microscopic examination – standard reference – obligatorily as a comparison to the autofluorescence method (test index). In selecting the two-phase studies, 17 of 3429 studies were included. The QUADAS-2 tool was used for risk of bias analysis with support from the Review Manager 5.0 tool for risk of bias analysis. The sensitivity and specificity of the studies varied considerably, with a minimum of 30% and a maximum of 100% for sensitivity, and a minimum of 15% and a maximum of 100% for specificity, which demonstrates exceptional accuracy within the studies. The risk of bias was low in most studies in domain 1 (patient selection) and unclear in most studies in domains 2 (index test), 3 (reference standard) and 4 (flow and time). The sensitivity and specificity of the studies varied considerably, with a minimum of 30 and a maximum of 100 for sensitivity and a minimum of 15 and a maximum of 100 for specificity, which demonstrates intellectual accuracy within the studies. The risk of bias was low in most studies in domain 1 (patient selection) and it was not clear in domains 2 (index test), 3 (reference standard) and 4 (flow and time). The autofluorescence of the selected studies showed moderate to uncertain accuracy due to the heterogeneity of the results and raises an alert for the development of more primary studies consistent in design and conduct.The applicability of autofluorescence in aiding the diagnosis of ODMPs should prosper ecause it is a non-invasive method, easy to handle, accessible in the dentist's routine, despite the variable cost, ubject to the standardization of protocols and the physician's experience., more studies are necessary due to the analysis of the risk of bias and the asymmetry of the sensitivity and specificity of the results.
- ItemAcurácia do dispositivo VELscope® para diagnóstico complementar de desordens orais potencialmente malignas (DOPMs)(Universidade Federal do Espírito Santo, 2023-12-19) Jesus, Eduarda Barboza Layber de; Barros, Liliana Aparecida Pimenta de; http://lattes.cnpq.br/8635277660080840; https://orcid.org/0009-0005-7083-4144; http://lattes.cnpq.br/4167117921403314; Barroso, Danielle Resende Camisasca; http://lattes.cnpq.br/3989074593181674; Lourenco, Simone de Queiroz ChavesThe early diagnosis of oral potentially malignant disorders (OPMDs) through visual inspection followed by histopathological confirmation is a fundamental step towards reducing the rates of lesions that have undergone malignant transformation. The use of the VELscope device has been suggested as an adjuvant tool through fluorescence visualization in the early detection of OPMDs. The aim of our study was to characterize the diagnostic accuracy of the VELscope in recognizing the autofluorescence of OPMDs, correlating clinical and histopathological aspects. Fifty-six oral mucosa lesions were submitted to conventional oral examination (COE) followed by VELscope and their autofluorescence characteristics were compared with the histopathological diagnosis. Sensitivity, specificity, positive and negative predictive values, accuracy and positive and negative likelihood ratios were calculated. The VELscope test showed sensitivity and specificity values of 50% and 69%, respectively, while the positive predictive value was 47.6% and the negative predictive value 71.4%. The overall accuracy was 62.5% and the positive and negative likelihood ratios were 1.63 and 0.72, respectively. The VELscope exam alone cannot provide a definitive diagnosis regarding the presence of dysplastic tissue changes and high-risk lesions. Despite having reasonable sensitivity, the high number of false-positive and false-negative results limits its effectiveness as an adjuvant, reinforced by the unfavorable negative likelihood ratio. A comprehensive and systematic conventional oral examination, biopsy and histopathological evaluation are the reference standards for the evaluation of suspicious lesions of the oral mucosa, considering the low accuracy of the VELscope device as an auxiliary method equipment in clinical examination.
- ItemAnálise Clínica e Micológica da Colonização Por Candida spp. em Leucoplasia Oral e Líquen Plano Oral(Universidade Federal do Espírito Santo, 2024-01-23) Novo, Vinícius Matos; Gonçalves, Sarah Santos; https://orcid.org/0000-0003-4170-4445; http://lattes.cnpq.br/1018708169217296; Velloso, Tânia Regina Grão; https://orcid.org/0000-0001-6865-7955; http://lattes.cnpq.br/6427157237870625; https://orcid.org/0000-0002-5892-210X; http://lattes.cnpq.br/4757635191749255; Velloso, Tânia Regina Grão; https://orcid.org/0000-0001-6865-7955; http://lattes.cnpq.br/6427157237870625; Barros, Liliana Aparecida Pimenta de; https://orcid.org/0000-0002-1649-3116; http://lattes.cnpq.br/8635277660080840; Pigatti, Fernanda Mombrini; https://orcid.org/0000-0001-8495-8571; http://lattes.cnpq.br/8243371686189167Colonization/infection by Candida spp. has been associated with a variety of oral entities, including oral leukoplakia and oral lichen planus, which are termed potentially malignant disorders of the oral cavity. These clinical conditions present distinct characteristics but share similarities in relation to etiological factors such as immunosuppression, chronic inflammation, and alterations in oral microbiota. Understanding the relationship between Candida spp. colonization and these lesions is fundamental for effective diagnosis and clinical management. This study aims to assess the prevalence of Candida colonization, delineate the demographic and clinical profile, phenotypically, biochemically, and molecularly identify Candida isolates, examine systemic and local factors contributing to Candida colonization and/or infection in oral leukoplakia and oral lichen planus, and investigate potential differences in in vitro susceptibility profiles of Candida isolates. Samples were obtained by swabbing lesions and intact oral mucosa for internal control, seeded on Sabouraud Dextrose and CHROMagar® Candida plates to assess colonization/infection and presumptive species identification; subsequently confirmed by matrix-assisted laser desorption/ionization time-of-flight (MALDITOF). Candida spp. prevalence was 36.8% and 18.2% in oral leukoplakia and oral lichen planus cases, respectively. Candida albicans was the sole species found in oral lichen planus lesions, n=2, 100%, and the most prevalent in oral leukoplakia, n=5, 76.4%. Among non-albicans Candida species in oral leukoplakia, C. parapsilosis (n=2, 25.5%) and C. tropicalis (n=1, 14.1%). Candida isolates, n=9, were susceptible to all tested antifungals. C. albicans was the most predominant species found in the studied lesions. Systemic and local factors showed no association in positive cases of oral lichen planus, but smoking and alcohol consumption may be associated with positive cases of oral leukoplakia, as well as the non-homogeneous clinical form. A possible predisposition to Candida colonization associated with epithelial dysplasia found in oral leukoplakia is suggested. The tested antifungal medications showed efficacy against the isolates.
- ItemAvaliação do impacto de problemas bucais na qualidade de vida de técnicos e enfermeiros hospitalares(Universidade Federal do Espírito Santo, 2022-12-13) Barbosa, Julia Saraiva de Almeida; Rosetti, Elizabeth Pimentel; http://lattes.cnpq.br/2693147990422431; https://orcid.org/0000-0002-0450-5642; http://lattes.cnpq.br/1389786016400324; Barcellos, Ludmilla Awad; https://orcid.org/0000-0003-3732-9515; http://lattes.cnpq.br/7262427405068645; Barros, Liliana Aparecida Pimenta de; https://orcid.org/0000-0002-1649-3116; http://lattes.cnpq.br/8635277660080840Objective: to evaluate the impact of oral problems on the quality of life of a hospital nursing team and its association with sociodemographic variables and stress. Methods: Cross-sectional study with a random sample of 111 nurses and nursing technicians from a university hospital. Three questionnaires were applied: Oral Health Impact Profile (OHIP-14), sociodemographic questionnaire and Bianchi Stress Scale. Fischer's exact test (p<0.05) found associations between each independent variable and the dimensions of the OHIP-14. To verify the strength of this association between event and exposure, the odds-ratio (OR) was calculated. To know the association between all the combined dimensions of the OHIP-14 (total score), with the independent variables, the Mantel-Haenzsel method was used, through the combined OR. Results: The prevalence of the impact of oral problems on quality of life was 51.4%. The dimensions with the greatest impact of oral problems were physical pain (37.8%) and psychological discomfort (35.1%), followed by physical disability (27.9%), psychological disability (26.1%), disability (18 .9%), functional limitation (15.3%) and social disability (11.7%). A higher frequency of oral health impact on quality of life was observed in individuals over 50 years of age (OR= 5.769, 95%CI= 1.806;18.431), single, widowed and divorced (OR= 2.396, 95%CI= 1.075;5.340), individuals with up to 12 years of schooling (OR= 2.766, 95%CI= 1.159;6.597), nursing technicians (OR= 4.073, 95%CI= 1.827;9.077) and individuals with up to 5 minimum wages (OR= 2.353, 95%CI = 1.080;5.127). In the relationship between stress and the impact of oral health, there was statistical significance in the dimensions disability (p=0.021), social disability (p=0.022) and psychological disability (p=0.045). Conclusion: Oral health conditions impact the quality of life of the hospital nursing team. Nursing technicians were more likely to have an impact on all dimensions that can be influenced by factors such as age, marital status, years of schooling, salary income and stress.
- ItemComparação Clínicopatológica e da Expressão da Citoqueratina-10 Entre Liquen Plano e Lesão Liquenoide Oral(Universidade Federal do Espírito Santo, 2024-03-07) Moreira, Milena Duarte; Barroso, Danielle Resende Camisasca; https://orcid.org/0000-0003-1193-2113; http://lattes.cnpq.br/3989074593181674; https://orcid.org/0009-0002-2952-7474; http://lattes.cnpq.br/0214358029056111; Barros, Liliana Aparecida Pimenta de; https://orcid.org/0000-0002-1649-3116; http://lattes.cnpq.br/8635277660080840; Silva Júnior, José de Assis; https://orcid.org/; http://lattes.cnpq.br/9737483962693792Background: Oral lichen planus malignant transformation potential has been largely debated. Cytokeratin-10 is suggested as an indicator of a dysplastic epithelium and can be used to assess malignant progression in oral potentially malignant disorders. This study aimed to compare clinical, histopathological features and immunostaining for cytokeratin-10 between oral lichen planus and oral lichenoid lesion. Methods: Retrospective longitudinal study comparing lichen planus and oral lichenoid lesions diagnosed at the Oral Pathological Anatomy Service, analysing socio-demographic, clinicopathological data and CK-10 expression. Chi-Square, Fisher's exact test and Mann-Whitney or Student's ttests were used, when appropriate; and p-values <.05 were considered significant. Results: A total of 23 lichen planus and 23 lichenoid lesions were included. There was an association between oral lichen planus and symptomatology (p=0.031). The buccal mucosa was the most affected site in both groups, 20 cases (87.0%) in lichen planus, and 16 cases (69.6%) in oral lichenoid lesion. Bilateral (p<0.001) striae (p=0.004) are more characteristic of oral lichen planus. There was an association of oral lichen planus with degeneration of the basal layer (p=0.049), as well as with mild epithelial dysplasia (p<0.001). Cytokeratin-10 immunostaining was similar between groups. Conclusion: A continuous follow-up is necessary to identify different patterns of malignant transformation between groups of lesions, as well as a comparison with lesions with a higher malignant transformation rate.
- ItemLeucoplasia oral e leucoplasia verrucosa proliferativa: análise clínico-patológica e imunohistoquímica(Universidade Federal do Espírito Santo, 2023-12-18) Pereira, Luanna Canal; Barroso, Danielle Resende Camisasca; http://lattes.cnpq.br/3989074593181674; https://orcid.org/0000-0001-9582-7067; http://lattes.cnpq.br/8124717525751212; Lourenço, Simone de Queiroz Chaves; Barros, Liliana Aparecida Pimenta de; http://lattes.cnpq.br/8635277660080840Introduction: Oral potentially malignant disorders (OPMDs) are a group of oral lesions associated with a variable risk of progression to oral carcinomas. Oral leukoplakia (OL) is the most common OPMD. Proliferative verrucous leukoplakia (PVL) is a subtype of OL with a high risk of progression to carcinoma. Cytokeratin 10 (CK10) acts to differentiate normal from dysplastic epithelium. Objectives: Compare sociodemographic, clinical, histopathological and immunohistochemical characteristics of CK10 in OL and PVL and apply two diagnostic criteria for PVL. Materials and methods: Cases diagnosed as OL, PVL, epithelial dysplasia and hyperkeratosis without and with dysplasia were selected from the Oral Pathological Anatomy Service of the Federal University of Espírito Santo, in ten years. Sociodemographic, clinicopathological and immunohistochemical data were collected. A p-value ≤.05 was considered was considered statistically significant. Results: 51 patients (n=32, 62.7% LVP and n=19, 37.3% LO) and 104 lesions (n=76, 73% LVP and n=28, 26.9% LO) were selected, with 53 lesions submitted to immunohistochemical staining for CK10 (n=40, 75.4% LVP and n=13, 24.5% LO), with a mean follow-up of 13 months for LO and 27 months for LVP (p=0.038). There was a predominance of females in both, an association between tobacco use and LO (p= 0.007) and the presence of recurrence in PVL lesions (p=0.028). There was malignant transformation in two cases of PVL and one of LO. Almost all lesions were positive for CK10 (n=51, 96.3%). No lesion showed CK10 expression in the basal layer. When applying the criteria for PVL, all met the criteria of Cerero-Lapiedra et al., 2010 and 19 patients met the criteria of Villa et al., 2018. Conclusions: Tobacco use is associated with LO, but not with LVP. The two criteria applied were useful, CereroLapiedra et al., 2010 selects more patients, a favorable fact for better monitoring of the disease. There was no difference in CK10 expression between the lesions studied.
- ItemPerfil do egresso de Odontologia no Brasil segundo as diretrizes curriculares nacionais : uma revisão sistemática(Universidade Federal do Espírito Santo, 2023-12-12) Bortolini, Nathalia Campos Dell'Orto Cardoso; Esposti, Carolina Dutra Degli; https://orcid.org/0000-0001-8102-7771; http://lattes.cnpq.br/7465412734380334; Pacheco, Karina Tonini dos Santos; https://orcid.org/0000-0002-4687-6062; http://lattes.cnpq.br/7465412734380334; https://orcid.org/0009-0002-7594-1078; http://lattes.cnpq.br/7573738538942492; Pessoa, Talitha Rodrigues Ribeiro Fernandes; https://orcid.org/0000-0001-8254-0876; http://lattes.cnpq.br/3454735703811810; Barros, Liliana Aparecida Pimenta de; https://orcid.org/0000-0002-1649-3116; http://lattes.cnpq.br/8635277660080840Faced with the challenge of training dental surgeons suitable for the Brazilian job market,with emphasis on the Unified Health System, in 2002, the National Curricular Guidelines (NCG) were established. These describe the professional profile and skills that professionals must develop in their training, guiding the curricula of undergraduate courses in Dentistry in Brazil. This study aimed to characterize the profile of graduates from Dentistry courses in Brazil according to the 2002 NCG, through a systematic review of the literature. The characterization of the graduate's profile was based on four sub-dimensions: generalist, humanist, autonomous, critical/reflective and capable of understanding social reality. The following guiding question was asked: What is the profile of graduates trained in Dentistry in Brazil according to the 2002 DCN? To identify relevant articles, searches were carried out in the databases PubMed, Embase, Scopus, Web of Science, Latin American and Caribbean Literature in Health Sciences (LILACS), Brazilian Bibliography of Dentistry (BBO), Scielo and the gray literature repositories Brazilian Digital Library of Theses and Dissertations (BDTD), CAPES Theses and Dissertations Catalog and Google Scholar, based on the keywords: graduates; trained; competency-based education; dentistry education; dentistry. Qualitative, quantitative and quantitative-qualitative studies were included that addressed the profile of Dentistry graduates in Brazil in Portuguese, English and Spanish and published since 2006. The methodological quality assessment of the included studies was carried out according to the Joanna Briggs Institutute Critical Appraisal Checklist for Systematic Reviews and Research. The risk of bias in these studies was considered moderate. 1,421 articles were identified, of which 13 were included in this review. The studies showed that the majority of graduates were female, aged between 26 and 30 years old, worked in the private sector, had some postgraduate qualifications and predominantly had a generalist profile.Considering the subdimensions evaluated, the results indicated greater representation in the generalist and autonomous subdimensions, to the detriment of the other subdimensions that comprise the graduate's profile. This result was especially evidenced by the positive influence of supervised curricular internships and the work of graduates in the public sector.