Ciências Odontológicas

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Navegando Ciências Odontológicas por Assunto "Candida spp."

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    Análise Clínica e Micológica da Colonização Por Candida spp. em Leucoplasia Oral e Líquen Plano Oral
    (Universidade Federal do Espírito Santo, 2024-01-23) Novo, Vinícius Matos; Gonçalves, Sarah Santos; https://orcid.org/0000-0003-4170-4445; http://lattes.cnpq.br/1018708169217296; Velloso, Tânia Regina Grão; https://orcid.org/0000-0001-6865-7955; http://lattes.cnpq.br/6427157237870625; https://orcid.org/0000-0002-5892-210X; http://lattes.cnpq.br/4757635191749255; Velloso, Tânia Regina Grão; https://orcid.org/0000-0001-6865-7955; http://lattes.cnpq.br/6427157237870625; Barros, Liliana Aparecida Pimenta de; https://orcid.org/0000-0002-1649-3116; http://lattes.cnpq.br/8635277660080840; Pigatti, Fernanda Mombrini; https://orcid.org/0000-0001-8495-8571; http://lattes.cnpq.br/8243371686189167
    Colonization/infection by Candida spp. has been associated with a variety of oral entities, including oral leukoplakia and oral lichen planus, which are termed potentially malignant disorders of the oral cavity. These clinical conditions present distinct characteristics but share similarities in relation to etiological factors such as immunosuppression, chronic inflammation, and alterations in oral microbiota. Understanding the relationship between Candida spp. colonization and these lesions is fundamental for effective diagnosis and clinical management. This study aims to assess the prevalence of Candida colonization, delineate the demographic and clinical profile, phenotypically, biochemically, and molecularly identify Candida isolates, examine systemic and local factors contributing to Candida colonization and/or infection in oral leukoplakia and oral lichen planus, and investigate potential differences in in vitro susceptibility profiles of Candida isolates. Samples were obtained by swabbing lesions and intact oral mucosa for internal control, seeded on Sabouraud Dextrose and CHROMagar® Candida plates to assess colonization/infection and presumptive species identification; subsequently confirmed by matrix-assisted laser desorption/ionization time-of-flight (MALDITOF). Candida spp. prevalence was 36.8% and 18.2% in oral leukoplakia and oral lichen planus cases, respectively. Candida albicans was the sole species found in oral lichen planus lesions, n=2, 100%, and the most prevalent in oral leukoplakia, n=5, 76.4%. Among non-albicans Candida species in oral leukoplakia, C. parapsilosis (n=2, 25.5%) and C. tropicalis (n=1, 14.1%). Candida isolates, n=9, were susceptible to all tested antifungals. C. albicans was the most predominant species found in the studied lesions. Systemic and local factors showed no association in positive cases of oral lichen planus, but smoking and alcohol consumption may be associated with positive cases of oral leukoplakia, as well as the non-homogeneous clinical form. A possible predisposition to Candida colonization associated with epithelial dysplasia found in oral leukoplakia is suggested. The tested antifungal medications showed efficacy against the isolates.