Ciências Odontológicas

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Programa de Pós-Graduação em Ciências Odontológicas

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Navegando Ciências Odontológicas por Assunto "Carcinoma de células escamosas"

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    Leucoplasia oral e leucoplasia verrucosa proliferativa: análise clínico-patológica e imunohistoquímica
    (Universidade Federal do Espírito Santo, 2023-12-18) Pereira, Luanna Canal; Barroso, Danielle Resende Camisasca; http://lattes.cnpq.br/3989074593181674; https://orcid.org/0000-0001-9582-7067; http://lattes.cnpq.br/8124717525751212; Lourenço, Simone de Queiroz Chaves; Barros, Liliana Aparecida Pimenta de; http://lattes.cnpq.br/8635277660080840
    Introduction: Oral potentially malignant disorders (OPMDs) are a group of oral lesions associated with a variable risk of progression to oral carcinomas. Oral leukoplakia (OL) is the most common OPMD. Proliferative verrucous leukoplakia (PVL) is a subtype of OL with a high risk of progression to carcinoma. Cytokeratin 10 (CK10) acts to differentiate normal from dysplastic epithelium. Objectives: Compare sociodemographic, clinical, histopathological and immunohistochemical characteristics of CK10 in OL and PVL and apply two diagnostic criteria for PVL. Materials and methods: Cases diagnosed as OL, PVL, epithelial dysplasia and hyperkeratosis without and with dysplasia were selected from the Oral Pathological Anatomy Service of the Federal University of Espírito Santo, in ten years. Sociodemographic, clinicopathological and immunohistochemical data were collected. A p-value ≤.05 was considered was considered statistically significant. Results: 51 patients (n=32, 62.7% LVP and n=19, 37.3% LO) and 104 lesions (n=76, 73% LVP and n=28, 26.9% LO) were selected, with 53 lesions submitted to immunohistochemical staining for CK10 (n=40, 75.4% LVP and n=13, 24.5% LO), with a mean follow-up of 13 months for LO and 27 months for LVP (p=0.038). There was a predominance of females in both, an association between tobacco use and LO (p= 0.007) and the presence of recurrence in PVL lesions (p=0.028). There was malignant transformation in two cases of PVL and one of LO. Almost all lesions were positive for CK10 (n=51, 96.3%). No lesion showed CK10 expression in the basal layer. When applying the criteria for PVL, all met the criteria of Cerero-Lapiedra et al., 2010 and 19 patients met the criteria of Villa et al., 2018. Conclusions: Tobacco use is associated with LO, but not with LVP. The two criteria applied were useful, CereroLapiedra et al., 2010 selects more patients, a favorable fact for better monitoring of the disease. There was no difference in CK10 expression between the lesions studied.
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    Manejo e prognóstico de pacientes com cancer de cabeça e pescoço durante a pandemia de COVID-19
    (Universidade Federal do Espírito Santo, 2023-05-17) Bruneli, Giuliano Lozer; Zeidler, Sandra Lucia Ventorin Von; https://orcid.org/0000000288975747; http://lattes.cnpq.br/5785612863130498; https://orcid.org/0000-0003-2277-5854; http://lattes.cnpq.br/4073059624940944; Spano, Liliana Cruz; https://orcid.org/0000000262056988; http://lattes.cnpq.br/7451382455806895; Velloso, Tânia Regina Grão; https://orcid.org/0000-0001-6865-7955; http://lattes.cnpq.br/6427157237870625
    The COVID-19 pandemic has brought the need for the implementation of several precautions to prevent the spread of the new coronavirus, as well as measures for its control. Among the changes adopted are those in healthcare services, particularly in oncology services. To provide support for the necessary changes in the oncology service, we analyzed the clinical and pathological data of patients diagnosed with HNSCC treated at the Head and Neck Surgery Service of the Hospital Santa Rita de Cássia (HSRC) between October 2020 and October 2021, comparing the clinical outcome of patients infected and not infected by SARSCoV-2. The diagnosis of SARS-CoV-2 infection was performed using the realtime PCR (RT-PCR) technique before the surgical procedure. To compare the clinical outcomes of patients regarding the presence of the new coronavirus infection, prognostic factors for HNSCC patients such as investigation of preexisting comorbidities and tumor staging (TNM System, 8th Ed) were also considered in addition to analyzing the viral load of patients referred for chemotherapy. The Chi-Square test was used to analyze associated variables, while the Kaplan-Meier model was used to calculate survival curves. Of the 194 recruited patients, 99 cases confirmed diagnoses of head and neck cancer and underwent surgical treatment. The most frequent comorbidities were hypertension and diabetes mellitus. The oral cavity and larynx were the most affected anatomical sites, with 51% and 33%, respectively. A total of 61.6% of cases were classified as T3/T4 and 53.4% did not show lymph node involvement. The presence of comorbidities and lymph node metastasis was associated with reduced survival. Of the 99 patients, 8.1% (8/99) were infected with SARS-CoV2, but no difference was observed in overall survival according to SARS-CoV-2 infection (p=0.086), and viral load was not associated with vital status (p=0.456). We concluded that the presence of SARS-CoV-2 infection did not influence overall survival in patients with HNSCC.